PMID: 6406031Jun 15, 1983Paper

The effect of liver cytosol on hepatic regeneration and tumor growth

Cancer
L MakowkaM J Phillips

Abstract

This report further evaluates the concept that the interaction of factors that originate within the liver can contribute, regulate or even initiate the actual development of hepatic regeneration after liver cell necrosis or partial hepatectomy. The effect of liver cytosol (100,000 g supernatant), both from intact adult rat liver (NLC) and from adult rat liver remnants that had been regenerating for 24 hours after 70% partial hepatectomy (PH) in posthepatectomy liver regeneration in the rat was studied. The specificity of the growth-controlling properties in liver cytosol was determined using tumor cells. The intraperitoneal administration of NLC after PH resulted in approximately 70-80% inhibition of the peak 3H-DNA specific activity seen in controls at 18 and 24 hours post-PH, with a significant increase in DNA synthesis at 31-40 hours post-PH. The intraperitoneal administration of RLC after PH, augmented the hepatic regenerative response normally produced. Autoradiographic determination of hepatic nuclear labeling confirmed the inhibitory and stimulatory properties of NLC and RLC respectively. Syngeneic NLC or RLC at six and 24 days after subcutaneous tumor inoculation resulted in significant inhibition of tumor growth for bo...Continue Reading

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Citations

Jan 1, 1989·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·D Henne-BrunsB Kremer
Nov 1, 1984·The Japanese Journal of Surgery·H IchihashiT Kondo
Mar 24, 1998·Annual Review of Medicine·S CaoE B Keeffe
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L BumgardnerD E Sutherland
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F KatsumotoF Nakayama
Feb 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W E Fleig, G Hoss
Nov 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z Q YaoF Y Yang
May 29, 1987·Biochemical and Biophysical Research Communications·A J StrainR D Milner
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·A J Strain

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