PMID: 18187868Jan 12, 2008Paper

The effect of local structural disruption on the yield of photochemical ligation between anthracene-oligonucleotide conjugates

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Pelin ArslanAkinori Jyo

Abstract

The techniques of chemical ligation have attracted great attention as an alternative to enzymatic joining of DNA ends. Here we introduce the photoligation of anthracene-modified ODN conjugates through anthracene cyclodimer formation. The effect of the positions and the kinds of single base mismatch on the template was evaluated using eight templates with one-base displacements. We found out that the yield of the ligation was affected by mispairing in a position-dependent manner. Such results would be attributed to the disruption of the local structure at the ligation site.

References

Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·M F Goodman
May 20, 1998·Genome Research·X ChenP Y Kwok
Jan 31, 2003·Organic Letters·Sandra Carriero, Masad J Damha
Sep 27, 2003·Nucleic Acids Research. Supplement·Toshihiro IharaAkinori Jyo
Jan 30, 2004·Journal of the American Chemical Society·Shinsuke SandoEric T Kool
Jul 22, 2004·Journal of the American Chemical Society·Toshihiro IharaAkinori Jyo
Aug 26, 2004·Nucleic Acids Research·Pingfang LiuLawrence C Sowers
Oct 30, 2004·Chemical Communications : Chem Comm·Jennifer L Czlapinski, Terry L Sheppard
Oct 30, 2004·Chemistry : a European Journal·Kurt V Gothelf, Raymond S Brown
Sep 27, 2005·Forensic Science International : Synergy·Beatriz SobrinoAngel Carracedo
Jun 2, 2006·Angewandte Chemie·Shinzi Ogasawara, Kenzo Fujimoto
Jul 19, 2006·Angewandte Chemie·Christian DoseOliver Seitz
Aug 15, 2006·Journal of Inorganic Biochemistry·Toshihiro IharaAkinori Jyo
Aug 15, 2006·Angewandte Chemie·Radiy R Islangulov, Felix N Castellano
Jan 26, 2007·Journal of the American Chemical Society·Christian SchäferDario Anselmetti
Mar 6, 2007·Journal of the American Chemical Society·Masaki NishijimaYoshihisa Inoue

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Citations

Jun 15, 2011·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Toshihiro IharaAkinori Jyo
Mar 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aya ShibataYoshihiro Ito
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Masoumeh TabatabaeeHamid Reza Kavasi
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Masoumeh TabatabaeeBernhard Neumüller
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Masoumeh TabatabaeeMasood Parvez
Sep 13, 2012·Acta Crystallographica. Section E, Structure Reports Online·Bahareh ShirinkamBernhard Neumuller

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