The effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of rats.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Ken-ichiro MatsumotoKazutoyo Endo

Abstract

The amounts of selenium (Se), iron (Fe), and zinc (Zn) in the liver, kidney, and spleen as a function of age of rats measured using instrumental neutron activation analysis were compared between Se-deficient (SeD) rats and normal rats. The SeD model rats can live for more than 50 weeks. The effect of Se-deficinecy in rats might be weak, compared to the marked malfunction of GSH-Px. The SeD rats can be considered as a model of nonlethal chronic oxidative stress. Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age.

Citations

May 25, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Tadashi ShimamuraSakae Yumoto
May 31, 2011·Experimental Gerontology·Paulo V G AlabarseMara S Benfato
Feb 7, 2018·Environmental Science and Pollution Research International·Neška VukšićIvica Budor

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Methods Mentioned

BETA
thermal neutron irradiation
Protein Assay

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