PMID: 8957747Oct 1, 1996Paper

The effect of long-term prednisone treatment on growth hormone and insulin-like growth factor-1

Journal of Endocrinological Investigation
M F PrummelE Endert

Abstract

Due to a lack of longitudinal data the precise effect of long-term corticosteroid treatment on serum levels of the anabolic hormones Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF-1) is unknown. Therefore, we prospectively followed GH and IGF-1 levels over a six month period in 18 euthyroid patients with Graves' ophthalmopathy. Ten patients were treated with a three month course of prednisone; eight patients receiving retrobulbar irradiation served as controls. Baseline serum GH and IGF-1 levels were similar in both groups. Whereas no changes were seen in controls, prednisone induced a rapid increase in serum IGF-1 levels, which was sustained during the entire treatment period: 18.2 +/- 5.2 at baseline vs 24.1 +/- 6.7 nmol/l after 12 weeks of treatment (p < 0.001). After discontinuation of prednisone IGF-1 returned to baseline levels. Basal GH levels were frequently undetectable, but during treatment GH values were lower in the prednisone group (median of detectable values 4.0 mU/L [range 2.0-26.0]) than in controls (11.8 [2.8-44.0]; p < 0.01). In conclusion, long-term prednisone treatment is associated with suppressed GH levels and with an increase in total IGF-1 levels. This suggests that prednisone can disrupt the...Continue Reading

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Citations

Dec 22, 2007·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Rui-Li WeiJi-Ping Cai
Dec 20, 2018·Brain Plasticity·A M FernandezI Torres Aleman
Jan 31, 2002·Journal of Endocrinological Investigation·F E Finamor, A M Lengyel
Jan 28, 2003·Journal of Pediatric Gastroenterology and Nutrition·Mark R CorkinsJoseph F Fitzgerald
Mar 21, 2019·International Journal of Molecular Sciences·Kok-Yong Chin, Soelaiman Ima-Nirwana
Feb 7, 2012·Breast Cancer Research : BCR·Gitte Vrelits SørensenTimothy L Lash
Mar 25, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Claes OhlssonLiesbeth Vandenput

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