PMID: 847235Feb 1, 1977Paper

The effect of loperamide on prostaglandin induced diarrhoea in rat and man

Prostaglandins
S M Karim, P G Adaikan

Abstract

Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins. This compound is effective in inhibiting prostaglandin induced fluid accumulation in the small intestine in rats. Loperamide also blocked smooth muscle stimulating action of prostaglandins, acetylcholine and histamine on gastrointestinal smooth muscle preparations from several laboratory animals.

Citations

Aug 17, 2001·Phytotherapy Research : PTR·A L AbdullahiC Wambebe
Mar 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·U M Farack, K Loeschke
Mar 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·E Beubler, F Lembeck
Sep 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·U M FarackK Loeschke
Jun 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·L Jivegård, J Svanvik
Mar 1, 1984·Digestive Diseases and Sciences·P A CannD Barends
Sep 1, 1986·Veterinary Research Communications·L Ooms, A Degryse
Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·H MiyazakiM Hashimoto
Apr 15, 1979·European Journal of Pharmacology·I MuramatsuM Nakashima
Oct 24, 1989·European Journal of Pharmacology·K LoeschkeU M Farack
Jun 1, 1985·Prostaglandins·A RobertM J Ruwart
Jan 1, 1996·Pharmacology & Therapeutics·A De Luca, I M Coupar
May 24, 2005·Journal of Ethnopharmacology·Abdulkarim AgunuEzzeldin Mukhtar Abdurahman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J F KachurM Field
Feb 1, 1993·Acta Paediatrica Japonica; Overseas Edition·T KidowakiH Takada
Jul 1, 1979·British Journal of Pharmacology·M F Piercey, M J Ruwart
Feb 1, 1978·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S S Ratnam, S M Karim
May 1, 1992·Acta Physiologica Scandinavica·A BerggrenA Rubenson
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·M V DiurnoF Capasso
Oct 1, 1977·Archives of Disease in Childhood·J A DodgeS Walker
Sep 1, 1981·Archives of Disease in Childhood·J A DodgeY Yamashiro
Jan 1, 1983·Archives of Disease in Childhood·B K SandhuJ T Harries
Aug 1, 1981·Gut·B K SandhuJ T Harries
Nov 1, 1982·The Journal of Clinical Investigation·L R SchillerJ S Fordtran
Jan 1, 1984·The Journal of Emergency Medicine·M Fossel, P Rosen
Dec 15, 1981·Biochemical Pharmacology·G F Baker, M B Segal
Mar 19, 2014·Pharmaceutical Biology·Gabriel A AgborProtus Arrey Tarkang
Dec 1, 1988·The Journal of Pharmacy and Pharmacology·N MascoloF Capasso
Jan 28, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Vanessa J Kumpf
Jul 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·M M GottschlichJ W Alexander
Dec 29, 2013·Journal of Virology·Claudia IstrateLennart Svensson
Oct 8, 2013·Pharmaceutical Biology·Shubhra Kanti DeyIsmet Ara Jahan
Nov 3, 2015·Obesity·Joseph C Anderson
Oct 1, 1977·Archives of Disease in Childhood·F E JohnsonJ R Lilly
Aug 1, 1981·The Journal of Pharmacy and Pharmacology·E H VerhaerenJ A Lemli
Jun 1, 1993·Digestive Diseases and Sciences·F AwoutersP A Janssen
Jun 1, 1987·Alimentary Pharmacology & Therapeutics·H Ruppin

Related Concepts

Abortion Failure
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