PMID: 847235Feb 1, 1977Paper

The effect of loperamide on prostaglandin induced diarrhoea in rat and man

S M Karim, P G Adaikan


Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins. This compound is effective in inhibiting prostaglandin induced fluid accumulation in the small intestine in rats. Loperamide also blocked smooth muscle stimulating action of prostaglandins, acetylcholine and histamine on gastrointestinal smooth muscle preparations from several laboratory animals.


Aug 17, 2001·Phytotherapy Research : PTR·A L AbdullahiC Wambebe
Mar 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·U M Farack, K Loeschke
Mar 20, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·E Beubler, F Lembeck
Sep 1, 1981·Naunyn-Schmiedeberg's Archives of Pharmacology·U M FarackK Loeschke
Jun 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·L Jivegård, J Svanvik
Mar 1, 1984·Digestive Diseases and Sciences·P A CannD Barends
Sep 1, 1986·Veterinary Research Communications·L Ooms, A Degryse
Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·H MiyazakiM Hashimoto
Apr 15, 1979·European Journal of Pharmacology·I MuramatsuM Nakashima
Oct 24, 1989·European Journal of Pharmacology·K LoeschkeU M Farack
Jun 1, 1985·Prostaglandins·A RobertM J Ruwart
Jan 1, 1996·Pharmacology & Therapeutics·A De Luca, I M Coupar
May 24, 2005·Journal of Ethnopharmacology·Abdulkarim AgunuEzzeldin Mukhtar Abdurahman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J F KachurM Field
Feb 1, 1993·Acta Paediatrica Japonica; Overseas Edition·T KidowakiH Takada
Jul 1, 1979·British Journal of Pharmacology·M F Piercey, M J Ruwart
Feb 1, 1978·The Australian & New Zealand Journal of Obstetrics & Gynaecology·S S Ratnam, S M Karim
May 1, 1992·Acta Physiologica Scandinavica·A BerggrenA Rubenson
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·M V DiurnoF Capasso
Oct 1, 1977·Archives of Disease in Childhood·J A DodgeS Walker
Sep 1, 1981·Archives of Disease in Childhood·J A DodgeY Yamashiro
Jan 1, 1983·Archives of Disease in Childhood·B K SandhuJ T Harries
Aug 1, 1981·Gut·B K SandhuJ T Harries
Nov 1, 1982·The Journal of Clinical Investigation·L R SchillerJ S Fordtran
Jan 1, 1984·The Journal of Emergency Medicine·M Fossel, P Rosen
Dec 15, 1981·Biochemical Pharmacology·G F Baker, M B Segal
Mar 19, 2014·Pharmaceutical Biology·Gabriel A AgborProtus Arrey Tarkang
Dec 1, 1988·The Journal of Pharmacy and Pharmacology·N MascoloF Capasso
Jan 28, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Vanessa J Kumpf
Jul 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·M M GottschlichJ W Alexander
Dec 29, 2013·Journal of Virology·Claudia IstrateLennart Svensson
Oct 8, 2013·Pharmaceutical Biology·Shubhra Kanti DeyIsmet Ara Jahan
Nov 3, 2015·Obesity·Joseph C Anderson
Oct 1, 1977·Archives of Disease in Childhood·F E JohnsonJ R Lilly
Aug 1, 1981·The Journal of Pharmacy and Pharmacology·E H VerhaerenJ A Lemli
Jun 1, 1993·Digestive Diseases and Sciences·F AwoutersP A Janssen
Jun 1, 1987·Alimentary Pharmacology & Therapeutics·H Ruppin

Related Concepts

Abortion Failure
Medicinal Plants Testing, Preclinical
Smooth Muscle
Prostaglandin Antagonists

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.