The effect of losartan on differential reflex control of sympathetic nerve activity in chronic kidney disease

Journal of Hypertension
Yimin YaoJacqueline K Phillips

Abstract

The effect of angiotensin II type I receptor (AT1R) inhibition on the pattern of reflex sympathetic nerve activity (SNA) to multiple target organs in the Lewis polycystic kidney (LPK) rat model of chronic kidney disease was determined. Mean arterial pressure (MAP), splanchnic SNA (sSNA), renal SNA (rSNA) and lumbar SNA (lSNA) were recorded in urethane-anaesthetized LPK and Lewis controls (total n = 39). Baroreflex, peripheral and central chemoreflex, and somatosensory reflex control of SNA (evoked by phenylephrine/sodium nitroprusside infusion, 10% O2 in N2 or 100% N2 ventilation, 5% CO2 ventilation and sciatic nerve stimulation, respectively) were determined before and after administration of losartan (AT1R antagonist 3 mg/kg, intravenous). Baseline MAP was higher in LPK rats and baroreflex control of sSNA and rSNA, but not lSNA, was reduced. Losartan reduced MAP in both strains and selectively improved baroreflex gain for sSNA (-1.2 ± 0.1 vs. -0.7 ± 0.07 %/mmHg; P < 0.05) in LPK. The peripheral and central chemoreflex increased MAP and all SNA in Lewis controls, but reduced or had no effect on these parameters, respectively, in LPK. The SNA response to somatosensory stimulation was biphasic, with latency to second peak less i...Continue Reading

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Citations

Jun 15, 2015·Current Hypertension Reports·Ibrahim M Salman
Sep 30, 2016·Pharmacological Reports : PR·Marta KuczeriszkaJanusz Sadowski
Oct 26, 2016·Autonomic Neuroscience : Basic & Clinical·Ibrahim M SalmanJacqueline K Phillips

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Methods Mentioned

BETA
urine collection

Software Mentioned

GraphPad Prism
GraphPad
Spike2

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