PMID: 3759569Aug 1, 1986Paper

The effect of low dose-rate and cyclophosphamide on the radiation tolerance of the mouse lung

International Journal of Radiation Oncology, Biology, Physics
S P LockhartG G Steel

Abstract

Mice were given cyclophosphamide 30 mg/kg intraperitoneally before thoracic irradiation at high dose-rate (HDR, 100 cGy/min) or low dose-rate (LDR, 5 cGy/min). The development of pneumonitis was monitored by regular measurement of breathing rate. Peak rises in breathing rate occurred around 4-9 weeks in those given cyclophosphamide before irradiation, and around 14-16 weeks in those given radiation alone, regardless of dose-rate. The dose reduction factor (DRF = LDR/HDR ratio) for LDR irradiation was congruent to 1.8 but LDR sparing was abolished (DRF congruent to 1.0) when cyclophosphamide was given before irradiation.

References

May 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J D DownG G Steel
Aug 1, 1985·The British Journal of Radiology·S Lehnert, W B Rybka
Jul 1, 1983·International Journal of Radiation Oncology, Biology, Physics·A BarrettR L Powles
Jul 1, 1983·International Journal of Radiation Oncology, Biology, Physics·R P Hill
Oct 1, 1981·International Journal of Radiation Oncology, Biology, Physics·T J KeaneW D Rider
Apr 1, 1981·International Journal of Radiation Oncology, Biology, Physics·J Van DykC J Fryer

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Citations

Sep 1, 1996·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A SafwatJ Overgaard
Jan 1, 1996·International Journal of Radiation Oncology, Biology, Physics·A SafwatJ Overgaard
Sep 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S P LockhartJ D Down
Oct 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·O S NielsenJ Overgaard
Aug 2, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mohamad B DabjanJulian D Down
Apr 29, 1998·Experimental Lung Research·Z VujaskovicA W Konings

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