Nov 22, 2005

The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study

Brain Research
P P BertrandMaarten van den Buuse

Abstract

Defects in serotonergic transmission, including serotonin transporter (SERT) function, have been implicated in depression, anxiety disorders and some aspects of schizophrenia. The sex steroid hormone estrogen is known to modulate functional SERT activity, but whether it is up- or down-regulated is unclear. The aim of the present study was to examine the effect of a low estrogen state in mice on the behavioral effect of drugs acting through the SERT, serotonin uptake kinetics and SERT density in the hippocampus. We compared control mice, ovariectomized (OVX) C57BL/6J mice and aromatase knockout (ArKO) mice that are unable to produce estrogen. Fluoxetine treatment, but not fenfluramine treatment, significantly increased prepulse inhibition (PPI), a measure of sensorimotor gating, in C57BL/6J mice. The effect of fluoxetine was greater in OVX compared to sham-operated mice. In ArKO and J129 wild-type mice, fluoxetine increased PPI to the same extent while fenfluramine increased PPI more in ArKO mice compared to controls. Measurement of the time-course for diffusion and reuptake of exogenous serotonin in the CA3 region of the hippocampus showed that, in OVX mice, the fluoxetine-induced slowing of signal decay after application of se...Continue Reading

Mentioned in this Paper

Neuro-Oncological Ventral Antigen 2
Thaw
Fenfluramine
Testosterone Measurement
Salicylhydroxamic acid
CYP19A1 gene
CNS - Brain - Hippocampus (Mmhcc)
Magnesium Measurement
Extracellular
Pellet Formation

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