The effect of low-level diode laser on COX-2 gene expression in chronic periodontitis patients

Lasers in Medical Science
Snezana PesevskaNikola Angelov

Abstract

Adjunctive treatments to scaling and root planing (SRP) such as lasers, have been utilized in the treatment of chronic periodontitis, mainly aiming to suppress and eliminate the bacteria, as well as enhancing the healing response. Eighty gingival papilla biopsy samples were obtained from 60 patients diagnosed with chronic advanced periodontitis; randomly assigned to three treatment groups (n = 20), as well as 20 subjects with no periodontal disease [group A]. Group B received SRP on a single quadrant/day for four consecutive days. On day 5, all quadrants were rescaled. Groups C and D received the same treatment as group B plus laser application with the low-level diode laser (630-670 nm, 1.875 J/cm2) for five and ten consecutive days, respectively. Papilla biopsies were obtained from subjects and evaluated by RT-PCR for expression of COX-2. The values in the control group were 0.028 0.014 and baseline values for the examined groups were 0.16 0.18. Significantly decreased level of COX-2 expression for groups C and D was found after treatment, while lowest average expression was found in the group that had the 10 laser treatments supplemental to SRP (0,035 0,014). The results of this study show suppression of COX-2 in gingival ti...Continue Reading

References

Aug 1, 1991·Journal of Periodontology·P StashenkoS S Socransky
Jan 1, 1987·Lasers in Surgery and Medicine·M A Trelles, E Mayayo
Nov 1, 1996·Annals of Periodontology·C M Cobb
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Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Anastasia PapafiliGeoffrey J Laurent
Aug 2, 2003·The Journal of the American Dental Association·Fan ZhangAndrew J Dannenberg
Feb 3, 2005·Photomedicine and Laser Surgery·Kazuhiro MizutaniTakashi Harada
Mar 1, 2006·Photomedicine and Laser Surgery·F AimbireJ M Bjordal
Sep 9, 2008·Journal of Clinical Periodontology·Frank SchwarzAnton Sculean
Nov 13, 2009·Journal of Periodontology·Pam BrahamRichard Darveau
Nov 26, 2009·Photomedicine and Laser Surgery·Ana PejcicRadmila Obradovic
Mar 8, 2011·Lasers in Medical Science·Snezana PesevskaSebastiano Andreana
May 17, 2011·Genetics and Molecular Research : GMR·K K OlT Isbir
Dec 8, 2011·Anais Brasileiros De Dermatologia·Juliana Aparecida de Almeida Chaves PivaRenata Amadei Nicolau

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Citations

Nov 22, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Leila GholamiReza Fekrazad
Aug 9, 2020·Dentistry Journal·Mark CronshawMartin Grootveld
Oct 11, 2020·Dentistry Journal·Mark CronshawMartin Grootveld

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