The effect of lumbar sympathetic stimulation on the vasculature of bone

British Journal of Pharmacology
M A Tran

Abstract

1 The nutrient artery to the tibia of anaesthetized dogs was perfused at a constant rate by blood from the femoral artery and the perfusion pressure in the artery, the intramedullary pressure of the bone and the pressure in the nutrient vein recorded. 2 Low frequency stimulation (1 to 5 HZ) of the lumbar sympathetic chain always increased the perfusion pressure but the intramedullary pressure sometimes increased, sometimes decreased and sometimes remained unchanged. 3 The alpha-adrenoceptor blocking agents, phentolamine (1 mg/kg i.v.) and dihydroergotamine (0.5 mg/kg i.v.) reduced or abolished these effects whereas the beta-adrenoceptor blocking agent, propranolol (1 mg/kg i.v.) did not modify them. 4 The nutrient vein end pressure did not differ significantly from the intramedullary pressure and underwent similar variations during stimulation of the lumbar sympathetic chain.

References

Nov 1, 1978·European Journal of Pharmacology·M A Tran, J P Géral
Jul 1, 1968·Acta Physiologica Scandinavica·K Michelsen
Sep 1, 1967·Acta Physiologica Scandinavica·K Michelsen
May 1, 1959·The American Journal of Physiology·E HERZIG, W S ROOT

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Citations

Mar 29, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kannayiram AlagiakrishnanAnne Sclater
Feb 6, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bernard RocheMarie-Hélène Lafage-Proust

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