The effect of magnesium on coagulation in parturients with preeclampsia

Anesthesia and Analgesia
M J HarnettK Bhavani-Shankar

Abstract

Preeclampsia is associated with complex coagulation abnormalities that include altered platelet function and consumption and activation of the fibrinolytic system. Magnesium sulfate, which is used as a therapeutic modality for the prevention of seizures in preeclamptic parturients, has anticoagulant and antiplatelet effects. We sought to determine the effects of magnesium on various components of the coagulation system in patients with preeclampsia. We assessed the coagulation status of 18 parturients with preeclampsia being treated with magnesium. The assessment was performed with the thromboelastograph test, which provides an overall assessment of blood coagulation via the coagulation index. Thromboelastography was performed before beginning magnesium therapy and 30 min and 2 h after a 6-g bolus of IV magnesium. The R value (time to first clot formation) was found to be significantly slower (P < 0.05) at 30 min after the magnesium bolus. This result suggests increased coagulant factor activity resulting from the magnesium bolus. However, there was no effect of magnesium on the overall coagulation, as evidenced by the lack of change in the coagulation index either at 30 min or at 2 h after the completion of the initial magnesi...Continue Reading

References

Dec 1, 1977·British Journal of Obstetrics and Gynaecology·C A Thornton, J Bonnar
Jan 1, 1990·Seminars in Thrombosis and Hemostasis·R P Rodgers, J Levin
Jan 1, 1989·American Journal of Obstetrics and Gynecology·K de BoerP E Treffers
Jan 1, 1989·American Journal of Obstetrics and Gynecology·C BenedettoC Tetta
Jul 1, 1987·American Journal of Obstetrics and Gynecology·P SamuelsD B Cines
Feb 1, 1982·American Journal of Obstetrics and Gynecology·C P Weiner, J Brandt
Jan 1, 1995·British Journal of Anaesthesia·M F James, G Neil
Nov 1, 1996·American Journal of Obstetrics and Gynecology·M Kynczl-Leisure, L A Cibils
Jul 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·V L SerebruanyP A Gurbel
Jan 10, 1998·American Journal of Obstetrics and Gynecology·D GrisaruA Eldor
Feb 18, 1998·American Journal of Obstetrics and Gynecology·J WangX L Wang
Aug 24, 2004·International Journal of Obstetric Anesthesia·M F James

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Citations

Apr 2, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·P DiemunschUNKNOWN Société française de anesthésie et de réanimation
May 19, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·A G M AyaJ Ripart
Oct 24, 2002·Journal of Clinical Anesthesia·David L HepnerKodali Bhavani-Shankar
May 2, 2020·Journal of Thrombosis and Haemostasis : JTH·Ariunzaya AmgalanHoma K Ahmadzia
Feb 12, 2004·Drugs·Nanda Gopal Mandal, Sridhar Surapaneni
Oct 30, 2009·Biological Trace Element Research·Mine GulabogluIlhan Delibas
Jul 11, 2020·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Mohammad Ali SahmeddiniMohammad Hossein Eghbal
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jong H ChoiChong M Park
Nov 26, 2013·American Journal of Obstetrics and Gynecology·Michaela Kristina FarberBhavani Shankar Kodali
Apr 18, 2003·Anesthesiology Clinics of North America·Jaya Ramanathan, Kelly Bennett
Dec 4, 2008·Thrombosis Research·Ana PortelinhaIrene Rebelo

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