The effect of magnesium on length of stay for pediatric sickle cell pain crisis

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
David C BrousseauJulie A Panepinto

Abstract

To determine the effect of intravenous (IV) magnesium sulfate on the length of stay (LOS) for children admitted with sickle cell pain crisis. This was a single arm study, with historical controls. Hemoglobin SS or Hemoglobin Sbeta degrees children admitted for pain crisis were eligible. Two sequential treatment protocols of IV magnesium sulfate were added to standard inpatient therapy of IV fluids, opioids, and nonsteroidal anti-inflammatory drugs. The initial 12 children received 40 mg/kg (maximum of 1.5 g) of IV magnesium in the emergency department (ED), and eight and 16 hours later. Seven subsequent children received 40 mg/kg (maximum of 2.5 g) of IV magnesium in the ED, and every eight hours for up to four inpatient days. The main outcome measure was LOS, measured in days. Differences in LOS were analyzed between the admission with magnesium, and the two previous admissions meeting the same criteria, using a Wilcoxon signed-rank test for nonparametric paired data. Nineteen children were enrolled. The results of the two protocols were combined for the analysis. A shorter LOS was found on study admissions (median LOS, 3.0 days compared with 5.0 and 4.0 days for the previous two admissions; p = 0.006). IV magnesium appears to...Continue Reading

Citations

Aug 27, 2013·Thrombosis Research·Payal C DesaiKenneth I Ataga
Nov 21, 2007·Hematology·Samir K Ballas
Jan 18, 2011·Hematology·Zaijie J WangRobert Molokie
Dec 10, 2013·Hematology·Deepa Manwani, Paul S Frenette
Aug 2, 2015·Blood·David C BrousseauUNKNOWN Pediatric Emergency Care Applied Research Network (PECARN)
Jul 8, 2017·Critical Reviews in Food Science and Nutrition·Agartha Ohemeng, Isaac Boadu
Apr 11, 2018·Biological Trace Element Research·Osama Omar YousifLamia Mustafa Al-Naama
Sep 1, 2019·Medicina·Charles Antwi-BoasiakoEbenezer Owusu Darkwa
Sep 10, 2019·The Cochrane Database of Systematic Reviews·Nan Nitra ThanLucia De Franceschi
Jan 21, 2014·Pediatric Blood & Cancer·Oluwakemi Badaki-MakunUNKNOWN Pediatric Emergency Care Applied Research Network (PECARN) Magnesium in Sickle Cell Crisis (MAGiC) Study Group
Jan 1, 2010·Nutrition and Metabolic Insights·H I HyacinthJ M Hibbert

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