PMID: 9422349Jan 9, 1998Paper

The effect of magnesium on oxidative neuronal injury in vitro

Journal of Neurochemistry
Raymond F ReganS S Panter

Abstract

The effect of magnesium on the oxidative neuronal injury induced by hemoglobin was assessed in murine cortical cell cultures. Exposure to 5 microM hemoglobin in physiologic (1 mM) magnesium for 26 h resulted in the death of about one-half the neurons and a sixfold increase in malondialdehyde production; glia were not injured. Increasing medium magnesium to 3 mM reduced neuronal death by about one-half and malondialdehyde production by about two-thirds; neuronal death and lipid peroxidation were approximately doubled in 0.3 mM magnesium. Comparable results were observed in spinal cord cultures. The NMDA antagonist MK-801 weakly attenuated hemoglobin neurotoxicity in low-magnesium medium, but tended to potentiate injury in physiologic magnesium. Incubation in low-magnesium medium alone for 24 h reduced cellular glutathione by approximately 50% in mixed neuronal and glial cultures but by only 10% in pure glial cultures. The iron-dependent oxidation of phosphatidylethanolamine liposomes was attenuated in a concentration-dependent fashion by 2.5-10 mM magnesium; a similar effect was provided by 0.01-0.1 mM cobalt. However, oxidation was weakly enhanced by 0.5-1 mM magnesium. These results suggest that the vulnerability of neurons to...Continue Reading

Citations

Jun 20, 2006·Archives of Environmental Contamination and Toxicology·Agnieszka ScibiorJarosław Ostrowski
May 26, 2010·Journal of Neurochemistry·Kellie M JaremkoRaymond F Regan
Dec 30, 2014·Physiological Reviews·Jeroen H F de BaaijRené J M Bindels
Oct 22, 2002·Expert Opinion on Investigational Drugs·Robert Vink, Alan J Nimmo
Mar 10, 2001·Mental Retardation and Developmental Disabilities Research Reviews·J J Volpe
Jun 27, 2009·Journal of Applied Toxicology : JAT·Agnieszka ScibiorIrmina Niedźwiecka
Jan 1, 2021·BioMed Research International·Hamidreza MohammadiMohammad Ali Ebrahimzadeh
Nov 14, 2020·Brain : a Journal of Neurology·Aimun A B JamjoomSeth G N Grant
Jun 3, 2018·Biochemical and Biophysical Research Communications·Jing Chen-RoetlingRaymond F Regan
Feb 13, 2001·Brain Research·D MaulikM Delivoria-Papadopoulos
Jul 11, 2002·European Journal of Pharmacology·Randall L BarbourBurton M Altura
Oct 15, 2003·Free Radical Biology & Medicine·Bret RogersRaymond F Regan
Jan 9, 2003·Clinics in Perinatology·Seetha Shankaran
Jun 16, 2009·Biochemical and Biophysical Research Communications·Jing Chen-RoetlingRaymond F Regan
Jul 27, 2011·Environmental Toxicology and Pharmacology·Agnieszka Scibior, Halina Zaporowska
Nov 3, 2010·Neuropharmacology·Jing Chen-RoetlingRaymond F Regan

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