Abstract
Perioperative magnesium sulfate (MgSO4) is used for analgesic, anti-arrhythmic, and obstetric purposes. The effects of MgSO4 on the neuromuscular blockade (NMB) induced by rocuronium, and the sugammadex reversal thereof, have not been clearly quantified. We investigated the effect of various MgSO4 concentrations on the NMB by rocuronium, and sugammadex reversal, in isolated left phrenic nerve hemi-diaphragm (PNHD) preparations from the rat. Rat PNHD preparations were randomly allocated to one of four groups varying in terms of MgSO4 concentration (1, 2, 3, and 4 mM, each n = 10, in Krebs solution). The train-of-four (TOF) and twitch height responses were recorded mechanomyographically. The preparations were treated with incrementally increasing doses of rocuronium and each group's effective concentration (EC)50, EC90, and EC95 of rocuronium were calculated via nonlinear regression. Then, sugammadex was administered in doses equimolar to rocuronium. The recovery index, time to T1 height > 95% of control, and the time to a TOF ratio > 0.9 after sugammadex administration were measured. The EC50, EC90, and EC95 of rocuronium fell significantly as the magnesium level increased. The EC50, EC90, and EC95 of rocuronium did not differ b...Continue Reading
References
Jul 1, 1967·The Journal of Physiology·W D Paton, D R Waud
Oct 1, 1972·Anesthesiology·B E Waud, D R Waud
Apr 1, 1984·American Journal of Obstetrics and Gynecology·J A PritchardS A Pritchard
Jul 1, 1997·British Journal of Anaesthesia·B KussmanM E Comunale
May 10, 2000·Clinical Pharmacokinetics·J F Lu, C H Nightingale
Oct 30, 1957·The Journal of Physiology·D H JENKINSON
Nov 29, 2005·British Journal of Anaesthesia·T O SeyhanK Akpir
Jan 20, 2006·Journal of Anesthesia·Akiko YoshidaMasahiko Takahashi
Mar 1, 1942·The Journal of Clinical Investigation·A W WinklerH E Hoff
Aug 26, 2006·Anesthesiology·Malin JonssonLars I Eriksson
Aug 23, 2008·Anesthesiology·Glenn S MurphyMargarita Nisman
Mar 11, 2009·Journal of Critical Care·Anton BomKaren Thomson
Sep 15, 2009·British Journal of Anaesthesia·M F M James
Nov 19, 2009·Acta Anaesthesiologica Scandinavica·C CzarnetzkiM R Tramèr
May 18, 2011·Acta Anaesthesiologica Scandinavica·L M StaalsM M J Snoeck
Oct 12, 2011·Acta Pharmacologica Sinica·Hong WangShi-tong Li
Dec 21, 2011·European Journal of Anaesthesiology·Grégory A HansPol C Hans
Mar 13, 2014·Anesthesiology·Christoph CzarnetzkiMartin R Tramèr
Jan 15, 2015·Acta Anaesthesiologica Scandinavica·C UnterbuchnerT Metterlein
Nov 13, 2015·Anaesthesia·A Abad-GurumetaUNKNOWN Evidence Anaesthesia Review Group
Apr 4, 2017·Korean journal of anesthesiology·Woon Seok KangShin Mi Song