The effect of magnesium sulphate on intubating condition for rapid-sequence intubation: a randomized controlled trial

Journal of Clinical Anesthesia
Mi-Hyun KimYoung-Tae Jeon

Abstract

We compared magnesium sulphate with control, ketamine, rocuronium prime, and large-dose rocuronium (0.9 mg/kg) with regard to intubation conditions during rapid-sequence induction. This is a prospective, randomized, double-blinded study. The setting is at an operating room in a university-affiliated hospital. One hundred ten patients scheduled for general anesthesia were randomly allocated to the following 5 groups in equal numbers. The control and rocuronium 0.9 groups received rocuronium 0.6 and 0.9 mg/kg, respectively; the ketamine group was given 0.5 mg/kg ketamine 2 minutes before 0.6 mg/kg rocuronium; the rocuronium prime group received 0.06 mg/kg rocuronium 3 minutes before 0.54 mg/kg rocuronium; and the magnesium group received 50 mg/kg magnesium sulphate. Intubation was initiated 50 seconds after the rocuronium injection. Intubating condition (primary outcome), rocuronium onset, rocuronium duration, train-of-four ratio upon intubation, and hemodynamic variables (secondary outcomes) were recorded. The excellent intubating condition was more frequent in the magnesium group (P < .05). Onset of neuromuscular block was shorter in the magnesium group than in the control, ketamine, and rocuronium prime groups (P < .05). No di...Continue Reading

Associated Clinical Trials

References

Apr 1, 1985·Anesthesiology·S SchwarzF F Foldes
Nov 1, 1984·Anaesthesia·R S Cormack, J Lehane
Oct 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Naguib
Jul 24, 2004·Anesthesia and Analgesia·TaeHyung HanJ A Jeevendra Martyn
Jul 20, 2007·Acta Anaesthesiologica Scandinavica·T Fuchs-BuderUNKNOWN 8th International Neuromuscular Meeting
Nov 13, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Pelin Traje TopcuogluSaadet Ozgen
Mar 20, 2010·Anesthesia and Analgesia·Mohammad El-Orbany, Lois A Connolly
Mar 3, 2011·Anesthesiology·Susanne HerroederMarkus W Hollmann

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Citations

Jul 28, 2021·The Journal of International Medical Research·Haiyan SunRen Liao
Aug 18, 2021·Brazilian Journal of Anesthesiology·Carlos Eduardo David de AlmeidaNorma Sueli Pinheiro Modolo

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