The effect of maintenance narrow-band ultraviolet B therapy on the duration of remission for psoriasis: a prospective randomized clinical trial

International Journal of Dermatology
Gonca BoztepeFikret Kölemen

Abstract

Narrow-band (311 nm) UVB is an effective treatment modality for moderate to severe psoriasis. The effect of maintenance narrow-band UVB on the duration of remission is unknown. To determine whether maintenance narrow-band UVB affects the duration of remission. After clinically significant improvement [defined as 75% reduction in the initial Psoriasis Area and Severity Index (PASI) = "PASI 75"], patients were randomly assigned to one of two groups, namely maintenance and no maintenance. The first group received 2 months of maintenance therapy; the second group received no further treatment. Both groups were followed up for 1 year. At the end of 12 weeks, 46 of 50 patients (92%) achieved "PASI 75". Of these 46 patients, 32 had plaque-type psoriasis and 14 had guttate-type psoriasis. The numbers of patients assigned to the maintenance and no maintenance groups were 22 and 24, respectively. At the end of the study, 12 of the 22 patients (55%) in the maintenance group and, by contrast, eight of the 24 patients (33%) in the no maintenance group were still in remission. When the patients in both groups were categorized according to the type of psoriasis, eight of 14 (57%) patients with plaque-type psoriasis in the maintenance group an...Continue Reading

References

Jan 1, 1978·Dermatologica·T Fredriksson, U Pettersson
Nov 1, 1992·The British Journal of Dermatology·E PicotJ Meynadier
Dec 1, 1988·The British Journal of Dermatology·C GreenB E Johnson
Jul 1, 1988·The British Journal of Dermatology·H van WeeldenJ C van der Leun
Sep 1, 1986·Journal of the American Academy of Dermatology·R S SternJ A Parrish
May 1, 1981·The Journal of Investigative Dermatology·J A Parrish, K F Jaenicke
Jun 24, 1995·Lancet·I D Young
Jan 20, 1999·The British Journal of Dermatology·P M GordonP M Farr
Jul 20, 1999·Journal of the American Academy of Dermatology·J Koo, M Lebwohl
Oct 16, 1999·Archives of Dermatology·R S SternD K Mills
Dec 18, 2003·JAMA : the Journal of the American Medical Association·Kenneth B GordonUNKNOWN Efalizumab Study Group

❮ Previous
Next ❯

Citations

Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Sunil Dogra, Dipankar De
Jun 4, 2014·Dermatologic Clinics·Mariam B Totonchy, Melvin W Chiu
Feb 14, 2016·American Journal of Clinical Dermatology·Dhwani Mehta, Henry W Lim
Mar 25, 2011·Journal of the American Academy of Dermatology·Whitney LapollaSteven R Feldman
Jun 20, 2014·The Journal of Dermatology·Hyeong Ho RyuSeong Jin Jo
Oct 31, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Filomena RussoMichele Pellegrino
Apr 9, 2019·The Cochrane Database of Systematic Reviews·Annabel MaruaniLaurence Le Cleach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.