The effect of manganese supply on thyroid hormone metabolism in the offspring of manganese-depleted dams

Biological Trace Element Research
Klaus EderM Kirchgessner

Abstract

The present study was performed to investigate the effect of manganese (Mn) supply on metabolism of thyroid hormones in the rat. A study with rats was carried out over two generations. Female rats were raised with a Mn-deficient diet (0.1 mg Mn/kg), and mated to produce a second generation. The male rats of the second generation were used as subjects for the investigation. They were divided into five groups and fed diets with Mn concentrations of 0.1, 0.5, 2.2, 10, and 46 mg/kg for 40 d. For assessment of thyroid hormone metabolism, concentrations of thyroid hormones in serum and activity of hepatic type I 5'deiodinase (5'D-1) were measured. Feeding diets with 0.1 mg Mn/kg impaired growth and food conversion, influenced parameters of thyroid hormone metabolism, and changed some clinical-chemical parameters, such as concentrations of total protein, albumin, calcium (Ca) and magnesium (Mg) as well as activity of alkaline phosphatase in serum. Regarding the thyroid hormone metabolism, rats fed the diet with a Mn level of 0.1 mg/kg had a higher 5'D-I activity in liver, and consequently a higher concentration of triiodothyronine in serum than the rats fed the other diets. In contrast, the concentrations of total and free thyroxine w...Continue Reading

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Citations

Mar 20, 2015·International Journal of Environmental Health Research·Ram B Jain, Y Sammy Choi
Jun 20, 2007·Neurotoxicology·O P Soldin, M Aschner
Mar 17, 2015·Biological Trace Element Research·Nusrat Shahab MemonMuhammad Waris
Oct 5, 2017·International Journal of Environmental Research and Public Health·Hong SuXialu Lin
May 20, 2019·Environmental Science and Pollution Research International·Chi ZhangFen Huang
Dec 11, 2019·Biological Trace Element Research·Sepide TalebiGholamreza Askari
Nov 11, 2003·The Journal of Nutrition·Wayne Chris Hawkes, Nancy L Keim
Feb 9, 2008·The American Journal of Clinical Nutrition·Margaret P RaymanGeoffrey J Beckett

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