The effect of maternal care on gene expression and DNA methylation in a subsocial bee

Nature Communications
Samuel V ArsenaultSandra M Rehan

Abstract

Developmental plasticity describes the influence of environmental factors on phenotypic variation. An important mediator of developmental plasticity in many animals is parental care. Here, we examine the consequences of maternal care on offspring after the initial mass provisioning of brood in the small carpenter bee, Ceratina calcarata. Removal of the mother during larval development leads to increased aggression and avoidance in adulthood. This corresponds with changes in expression of over one thousand genes, alternative splicing of hundreds of genes, and significant changes to DNA methylation. We identify genes related to metabolic and neuronal functions that may influence developmental plasticity and aggression. We observe no genome-wide association between differential DNA methylation and differential gene expression or splicing, though indirect relationships may exist between these factors. Our results provide insight into the gene regulatory context of DNA methylation in insects and the molecular avenues through which variation in maternal care influences developmental plasticity.

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Citations

Jul 11, 2019·Proceedings. Biological Sciences·Nicholas W Saleh, Santiago R Ramírez
Aug 15, 2019·Biology Letters·Priscila Karla Ferreira SantosKaren M Kapheim
May 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Karen M KapheimWilliam T Wcislo
Jul 1, 2020·Genome Biology and Evolution·Hollie MarshallEamonn B Mallon
Oct 23, 2019·Evolution Letters·Hollie MarshallEamonn B Mallon
Aug 14, 2019·Genome Biology and Evolution·Boris YagoundEmily J Remnant
Dec 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Boris YagoundBenjamin P Oldroyd
Apr 20, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Benjamin P Oldroyd, Boris Yagound
May 11, 2021·Frontiers in Behavioral Neuroscience·Rebecca R Westwick, Clare C Rittschof
Jul 30, 2021·Molecular Ecology·Carlos A M Cardoso-JúniorBenjamin P Oldroyd
Dec 4, 2021·Molecular Ecology Resources·Claire Morandin, Volker P Brendel

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Methods Mentioned

BETA
protein folding
PCR

Software Mentioned

Tophat
edgeR
R package “ pvclust
UpSetR
rMATS
MethylKit
Rsubread featureCounts
Trimmomatic
PAML
DEXseq

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