The effect of maternal obesity on fatty acid transporter expression and lipid metabolism in the full-term placenta of lean breed swine

Journal of Animal Physiology and Animal Nutrition
L TianP S Yan

Abstract

This study was conducted to evaluate the influence of back-fat thickness (BF), at mating of sows, on the maternal and newborn circulating lipids, expression of placental fatty acids (FA) transporters and lipid accumulation in placenta. Full-term placentas were obtained by vaginal delivery from BFI (9-14 mm; n = 37), BFII (15-19 mm; n = 43) and BFIII (20-27 mm; n = 38) sows according to BF at mating, and frozen placental sections were analysed for fat accumulation. Blood samples were collected from the sows of day 105 pregnancy and from cord blood at delivery. mRNA and protein expression levels were evaluated with real-time RT-PCR and Western blotting. Our results demonstrated that BFII females had significantly increased litter weight and placental efficiency, decreased maternal triglyceride (TG) and non-esterified fatty acids (NEFA) levels, decreased maternal IL-6, TNFα and leptin levels compared to BFIII females (p < .05). BFIII sows were associated with significantly decreased newborn TG levels, increased newborn glucose, IL-6 and TNFα levels compared to BFI or BFII sows (p < .05). BFI and BFII females had significantly decreased placental TG, NEFA and cholesterol (CHOL) contents compared to BFIII females (p < .05). Moreover...Continue Reading

References

Dec 7, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S R De VrieseA B Christophe
Mar 21, 2003·Biochemical and Biophysical Research Communications·Johannes V SwinnenGuido Verhoeven
Apr 4, 2006·Journal of Animal Science·G R FoxcroftM D A Vinsky
Apr 14, 2006·Hormone Research·E HerreraH Ortega
Aug 24, 2006·Journal of Lipid Research·A L Magnusson-OlssonT L Powell
Oct 3, 2006·Cell Metabolism·Stephen R Farmer
Jul 12, 2007·Seminars in Immunopathology·Corinne RusterholzWolfgang Holzgreve
Oct 24, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G Miller Jonakait
Apr 30, 2008·Annals of the New York Academy of Sciences·Mostafa MetwallyTin Chiu Li
Nov 27, 2008·Journal of Lipid Research·Ira J GoldbergNada A Abumrad
Dec 2, 2008·Progress in Lipid Research·Asim K Duttaroy
Jan 3, 2009·The Journal of Biological Chemistry·Zheng Zheng LiAriel E Feldstein
May 20, 2009·The Journal of Physiology·A L FowdenG J Burton
Jul 23, 2009·The British Journal of Nutrition·Asli AkyolSarah McMullen
Apr 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Christopher J Brewer, Adam H Balen
May 5, 2010·Annual Review of Nutrition·Paul Haggarty
Jul 20, 2010·Animal Reproduction Science·W S Amaral FilhaF P Bortolozzo
Sep 17, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mei J ZhuStephen P Ford
May 19, 2011·American Journal of Physiology. Endocrinology and Metabolism·Sandra L RebholzLaura A Woollett
Jul 14, 2011·American Journal of Physiology. Endocrinology and Metabolism·Margarete DigelJoachim Füllekrug
Dec 3, 2014·Atherosclerosis·Yuan LiChao-Ke Tang

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Citations

Jun 28, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Tian LiangWen Aiyou
Oct 18, 2018·Journal of Animal Science·Shanice K KrombeenTiffany A Wilmoth
Aug 15, 2019·Animals : an Open Access Journal From MDPI·Ji-Wei LiPei-Shi Yan
May 14, 2020·Current Vascular Pharmacology·A L FowdenA N Sferruzzi-Perri

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