The effect of maternal soluble FMS-like tyrosine kinase 1 during pregnancy on risk of preterm delivery.

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Jennifer K StraughenV K Misra

Abstract

Soluble fms-like tyrosine kinase 1 (sFlt1) is an antiangiogenic protein that is associated with a number of disorders of placental angiogenesis. It has been hypothesized that disruption of placental angiogenesis may contribute to the pathophysiology of preterm delivery (PTD). However, the relationship of PTD risk to variation in sFlt1 levels is not well known. We investigate the relationship between longitudinal variation in maternal serum concentrations of sFlt1 and risk of PTD. Data were collected in a longitudinal cohort study involving 278 pregnant women. Maternal serum sFlt1 concentrations were measured at 6-10, 10-14, 16-20, 22-26, and 32-36 weeks gestation. Data analyses used longitudinal regression models using repeated measures that allow robust inferences from our modest sample size. The outcome was birth prior to 37 weeks gestation. sFlt1 concentrations were higher in first trimester for preterm compared to term deliveries. This relationship reversed in second trimester because sFlt1 concentrations increased more rapidly across gestation for term deliveries. In Cox proportional hazards analyses, a 2 ng higher sFlt1 concentration across gestation was associated with a hazard ratio of 1.3 (95% CI: 1.1, 1.5) for PTD sug...Continue Reading

References

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Nov 20, 2002·American Journal of Obstetrics and Gynecology·Yeon Mee KimRoberto Romero
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Oct 18, 2011·American Journal of Obstetrics and Gynecology·Stefan VerlohrenHolger Stepan

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Citations

Sep 27, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Tiffany A Moore SimasSharon E Maynard
Mar 15, 2013·Thrombosis Research·Anat Aharon, Benjamin Brenner
Mar 17, 2016·American Journal of Obstetrics and Gynecology·Heather A FreyGeorge A Macones
Jun 4, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·T AkhterT Naessen
Oct 2, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·K D KolstadJ F Simard

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