PMID: 11927392Apr 3, 2002Paper

The effect of maternal undernutrition on ovine fetal growth

The Journal of Endocrinology
J C OsgerbyT S Gadd

Abstract

Modifications in maternal nutrition during pregnancy can significantly disrupt fetal growth and subsequent post-natal health and survival. This study investigated the effects of undernutrition on fetal growth and the potential mechanisms involved. Tissue from pregnant ewes (n=27) was investigated on days 45, 90 and 135 of gestation (term = approximately 150 days). The thoracic girth (P<0.05) was greater in fetuses from nutrient restricted ewes on day 45 and there was also a trend towards an increased gut weight (P<0.08). By day 90, the fetal brain and thymus weight were lighter in underfed than in well-fed animals whilst the weight of the fetal ovaries was heavier (P<0.05). On day 135 the fetal heart, pancreas, thymus, gut and kidney weights were lighter in undernourished ewes (P<0.05). When expressed as a percentage of fetal body weight, significance was retained in the heart, pancreas and thymus (P<0.05). Bone growth was also affected. At day 90 the fetal femur and metatarsal were longer in underfed mothers (P<0.05). In contrast, the fetal humerus and scapula were shorter in underfed than in well-fed animals on day 135 (P<0.05) when the weight of the semitendinosus muscle (P<0.05) was also reduced. The fall in fetal glucose (...Continue Reading

Citations

Feb 1, 2003·Theriogenology·Victoria J TaylorD Claire Wathes
Feb 28, 2003·Biology of Reproduction·Hyukjung KwonGuoyao Wu
Jul 12, 2003·Biology of Reproduction·Hyukjung KwonThomas E Spencer
Nov 14, 2003·Biology of Reproduction·Hyukjung KwonThomas E Spencer
Dec 4, 2004·Biology of Reproduction·Guoyao WuThomas E Spencer
May 27, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Hyungchul HanStephen P Ford
May 28, 2010·The Journal of Nutrition·Arantzatzu LassalaGuoyao Wu
Jan 9, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Anna T Grazul-BilskaKimberly A Vonnahme
Jan 28, 2006·The Journal of Physiology·A L FowdenM Constancia
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Aug 16, 2008·Domestic Animal Endocrinology·M A VelazquezD C Wathes
May 13, 2008·American Journal of Physical Anthropology·Julienne N Rutherford, Suzette D Tardif
Mar 21, 2016·Molecular and Cellular Endocrinology·Laura D Brown, William W Hay
Apr 8, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Lacey LutzDonal C Skinner
Apr 11, 2008·Experimental Hematology·Evan CollettiChristopher D Porada
Jul 28, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Feng DongJun Ren
Apr 22, 2015·Molecular and Cellular Endocrinology·Jennifer A HetzMarilyn B Renfree
Jun 12, 2016·Physiology & Behavior·Damien S HunterKathryn L Gatford
Dec 15, 2016·Reproduction in Domestic Animals = Zuchthygiene·D ĐuričićM Samardžija
Jan 26, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Christopher D PoradaEsmail D Zanjani

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