The effect of meal size on postprandial carbohydrate metabolism in normal and tumor-bearing rats

Nutrition
Omar A ObeidP W Emery

Abstract

Doubling the size of a meal causes less than a two-fold increase in the thermic effect of feeding. One possible reason for this is that larger meals may be associated with a change in the pathway of postprandial hepatic glycogen synthesis from the indirect pathway, involving gluconeogenesis, to the more energetically efficient direct pathway. We have therefore investigated the effect of meal size on the relative contributions of those two pathways both in normal rats and in tumor-bearing rats, which have previously been shown to utilize the indirect pathway to a greater extent. Rats bearing a transplantable Leydig cell tumor and freely fed controls were fasted overnight and given a test meal amounting to 12 or 24 kJ of their normal diet. They were then injected with 3H2O and 14C-glycerol and killed one hour later. The total amount of 3H incorporated into liver glycogen was not affected by meal size, although it was greater in tumor-bearing rats than controls. Analysis of the 3H labelling at different positions in the glycogen glucose residues showed that the proportion of glycogen synthesized via pyruvate, which tended to be greater in tumor-bearing rats, was significantly reduced by increasing the size of the meal. Glycogen sy...Continue Reading

References

Mar 22, 1979·Biochimica Et Biophysica Acta·B A CookeH J van der Molen
Jan 1, 1987·Annual Review of Nutrition·J D McGarryJ Katz
Aug 1, 1970·The American Journal of Clinical Nutrition·P Fábry, J Tepperman
Dec 1, 1984·The Journal of Clinical Investigation·J Katz, J D McGarry
Aug 1, 1984·Metabolism: Clinical and Experimental·J O HillM DiGirolamo
Jul 10, 1948·The Journal of Nutrition·N GLICKMAN, H H MITCHELL

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Citations

May 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·O A ObeidP W Emery
Jul 14, 2018·Archives of Insect Biochemistry and Physiology·Zhaorigetu HubhachenJack W Dillwith

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