The effect of meals on bone turnover - a systematic review with focus on diabetic bone disease

Expert Review of Endocrinology & Metabolism
Rasmus Fuglsang-NielsenPeter Vestergaard

Abstract

Type 2 diabetes is associated with an increased risk of bone fractures. Bone mineral density (BMD) is increased and bone turnover is low in type 2 diabetes and the increased BMD does not explain the increased fracture risk. However, the low bone turnover may lead to insufficient bone renewal with unrepaired micro-cracks and thus increase fracture risk. Ingestion of food acutely decreases bone resorption markers and the macronutrient composition of meals and meal frequency may influence bone metabolism adversely in subjects with unhealthy eating patterns, e.g., patients with type 2 diabetes. The treatment strategy of bone disease in type 2 diabetics is covered in this review. The current management of diabetic bone disease consists of anti-osteoporotic treatment. However, anti-resorptives may further reduce an already low bone turnover with uncertain effects. Furthermore, the acute and long-term effects of meal ingestion, weight loss alone and in combination with exercise as well as the possible underlying mechanisms are covered in this systematic review. Current management of diabetic bone disease is based on principles of anti-osteoporotic treatment in non-diabetic subjects. However, studies are urged to investigate whether an...Continue Reading

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Citations

Aug 10, 2019·Current Osteoporosis Reports·Jakob Starup-LindeAase Handberg
Jun 13, 2020·Current Osteoporosis Reports·R ViggersJ Starup-Linde
Dec 2, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·Ann BjørnshaveJakob Starup-Linde

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