The effect of mechanical loading on the MyHC synthesis rate and composition in rat plantaris muscle

International Journal of Sports Medicine
A PehmeT Seene

Abstract

The aim of this study was to investigate the response of protein synthesis rate, particularly myosin heavy chain (MyHC) isoforms synthesis and the magnitude of its isoform transformation in fast-twitch plantaris muscle, to different modes of prolonged mechanical loading. Different protocols of mechanical loading were used: resistance training (RT), compensatory hypertrophy (CH) of m. plantaris after tenotomy of m. gastrocnemius and a combination of the two previous loadings (RT + CH). During the different modes of loading, plantaris muscle hypertrophy in RT group was approximately 10 %, CH approximately 40 % and CH + RT approximately 44 %. MyHC I and IID isoform synthesis rate increased in all experimental groups, as well as their relative content. MyHC IIA relative content decreased during RT and RT + CH and increased during CH. MHC IIB isoform relative content decreased in all experimental groups, but compared with CH in CH + RT MyHC IIB isoform content increased in plantaris muscle. These results demonstrate that different modes of mechanical loading resulted in the selective up- and down-regulation of MyHC isoforms in fast-twitch skeletal muscle. The synthesis rate and relative content of the two fastest isoforms of MyHC II...Continue Reading

Citations

Jun 26, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Priit KaasikTeet Seene
Mar 30, 2017·Revista da Associação Médica Brasileira·Stella Maris Lins TerenaRaquel Agnelli Mesquita-Ferrari
Nov 16, 2005·Medicine and Science in Sports and Exercise·Jakob L VingrenKim C Westerlind
Nov 19, 2005·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Stephen E AlwayDavid C Butler

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