The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries

Applied Bionics and Biomechanics
Hanna E Burton, Daniel M Espino

Abstract

Surface roughness can be used to identify disease within biological tissues. Quantifying surface roughness in the coronary arteries aids in developing treatments for coronary heart disease. This study investigates the effect of extreme physiological loading on surface roughness, for example, due to a rupture of an artery. The porcine left anterior descending (LAD) coronary arteries were dissected ex vivo. Mechanical overloading was applied to the arteries in the longitudinal direction to simulate extreme physiological loading. Surface roughness was calculated from three-dimensional reconstructed images. Surface roughness was measured before and after damage and after chemical processing to dehydrate tissue specimens. Control specimens confirmed that dehydration alone results in an increase of surface roughness in the circumferential direction only. No variation was noted between the hydrated healthy and damaged specimens, in both the longitudinal (0.91 ± 0.26 and 1.05 ± 0.25 μm) and circumferential (1.46 ± 0.38 and 1.47 ± 0.39 μm) directions. After dehydration, an increase in surface roughness was noted for damaged specimens in both the longitudinal (1.28 ± 0.33 μm) and circumferential (1.95 ± 0.56 μm) directions. Mechanical ov...Continue Reading

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Citations

Jul 23, 2020·Perfusion·Samuel TaylorDaniel M Espino
Nov 25, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Rhiannon NortheastDaniel M Espino

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Methods Mentioned

BETA
dissection
chemical treatment

Software Mentioned

Minitab Statistical

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