The effect of medium chain and long chain triglycerides incorporated in self-nano emulsifying drug delivery systems on oral absorption of cannabinoids in rats

International Journal of Pharmaceutics
Dvora IzgelovAmnon Hoffman

Abstract

The aim of this research was to investigate the effect of the lipid component in self-emulsifying drug delivery systems on the oral absorption of major cannabinoids Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD). The investigated lipids were either long chain triglycerides (LCT) or medium chain triglycerides (MCT) with different composition, fatty acid chain length, degree of saturation and their absorption pathway to the systemic circulation. Formulations were developed with the purpose of creating thermodynamically stable oil-in-water nano emulsions/suspensions with particle size of 50 nm or less which carry the lipophilic drug and increase water solubility. Following a methodic screening of suitable excipients in-vitro, leading formulations based on sesame oil or MIGLYOL® 812N (Type I LCT/MCT SNEDDS) and cocoa butter or tricaprin (Type II LCT/MCT SNEDDS) were investigated in the freely moving rat model. Results in rat model demonstrated that the effect of each type of lipid on bioavailability of cannabinoids is not straightforwardly anticipated. The differences in the effect of LCT and MCT on absorption was not substantial for Type I formulations, however, more prominent for Type II formulations. This unpredictable beha...Continue Reading

Citations

Jul 4, 2020·Drug Development and Industrial Pharmacy·Eleftherios G AndriotisDimitrios G Fatouros
Jan 6, 2021·AAPS PharmSciTech·Eleftherios G AndriotisDimitrios G Fatouros
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadine Monika FranckeHeike Bunjes
May 25, 2021·Critical Reviews in Food Science and Nutrition·Kelly Light, Salwa Karboune
Jul 31, 2021·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Ravindra PandeyBina Gidwani

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