PMID: 39845Jul 1, 1978

The effect of medroxyprogesterone acetate on blood pressure

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
H R BlackA DeCherney


Twenty-four women (21 normotensive and 3 hypertensive) aged 16-35 years received 150-mg injections of medroxyprogesterone acetate (MPA) for contraception. Their blood pressure (BP) was measured under basal conditions by the same nurse before treatment and at 1-, 2- and 3-month intervals. Their mean BP fell from 124.1/79.4 to 119.8/74.6 mm Hg at one month (p less than 0.05 for diastolic pressure) to 117.0/74.9 mm Hg at two months and to 115.6/73.2 mm Hg at three months. When the normotensive patients were analyzed separately, their BP fell, but not significantly. Only one patient had a rise of 20 mm Hg systolic, but she remained normotensive. We conclude that medroxyprogesterone acetate does not raise BP.


Jan 1, 1977·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S P Ellinas
Oct 1, 1975·Contraception·H A Nash
Jul 1, 1974·Progress in Cardiovascular Diseases·W B Kannel
Jan 1, 1971·Annals of Internal Medicine·M G CraneW Winsor
Jul 1, 1972·Annals of Internal Medicine·B J Zacherle, J A Richardson
Sep 1, 1972·American Journal of Obstetrics and Gynecology·G Leiman
Mar 23, 1974·British Medical Journal·R J WeirE Wilson
Oct 1, 1955·The Journal of Clinical Endocrinology and Metabolism·R L LANDAUM E KASCHT
Nov 1, 1958·The Journal of Clinical Endocrinology and Metabolism·R L LANDAU, K LUGIBIHL

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