PMID: 9526849Apr 4, 1998Paper

The effect of melatonin chronic treatment upon macrophage and lymphocyte metabolism and function in Walker-256 tumour-bearing rats

Journal of Neuroimmunology
E MartinsL F Costa Rosa

Abstract

Melatonin is the main hormone involved in the neuroendocrine-immune axis. It also presents antitumour activity. To evaluate the role of melatonin on the progression of Walker-256 tumour in rats we determined the effect of the hormone on some biochemical and functional aspects of macrophage and lymphocytes from cachectic rats. An important finding observed in immune cells from tumour-bearing (TB) rats is the impairment on glutamine and glucose metabolism in such cells. These changes are very similar to those observed in pinealectomized rats (PNX). The increased production of lactate and the flux of glucose through the Krebs cycle and the reduction in glutamine consumption seems to be involved in the immunosuppression presented in the TB and PNX animals. Melatonin treatment restored the changes observed in the metabolism of glucose and glutamine and stimulated the proliferation of lymphocytes from tumour-bearing rats. The results indicate that the effect of melatonin upon tumour growth involves the stimulation of the immune system by the hormone.

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Citations

Jul 18, 2012·Bulletin of Experimental Biology and Medicine·E L LushnikovaD V Morozov
Oct 26, 2011·World Journal of Gastroenterology : WJG·Chun-Qiu ChenMartin Storr
Jul 18, 2009·European Journal of Applied Physiology·Ronaldo Vagner Thomatieli dos SantosLuis Fernando Bicudo Pereira Costa Rosa
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Apr 5, 2019·Journal of Cellular Physiology·Yu-Hua ChaoShun-Fa Yang
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Jul 5, 2019·Journal of Cellular Physiology·Fatemeh MoradkhaniMohammad Hossein Asghari
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Jul 30, 2020·Journal of Cellular Physiology·Carmen RodríguezVanesa Martín
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Sep 8, 2004·Life Sciences·Ana Carolina Franco FerreiraLuís Fernando Bicudo Pereira Costa Rosa

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