The effect of melatonin on early postoperative cognitive decline in elderly patients undergoing hip arthroplasty: A randomized controlled trial

Journal of Clinical Anesthesia
Yunxia FanDapeng Gao

Abstract

The purpose of the present study was to investigate whether exogenous melatonin supplementation could ameliorate early postoperative cognitive decline (POCD) in aged patients undergoing hip arthroplasty with spinal anesthesia. Prospective cohort study. Department of Anesthesiology, Jinling Hospital, Nanjing University, Nanjing, China. One hundred and thirty-nine patients with ASA I-III, older than 65yr of age (mean age: 74.5±5.5; gender: male 53 and female 86), scheduled for hip arthroplasty were included in the present study. Patients were randomized to receive 1mg oral melatonin or placebo daily 1h before bedtime one day before surgery and for another 5 consecutive days postoperatively. The subject assessment, including Mini-Mental State Examination (MMSE) score, subjective sleep quality, general well-being, postoperative fatigue, and visual analogue scale for pain were evaluated pre-operatively and at days 1, 3, 5, and 7 after surgery. The MMSE score in the control group decreased significantly after surgery when compared with its own preoperative value or the melatonin group at days 1, 3, and 5. However, the MMSE score in the melatonin group remained unchanged during the 7days of monitoring. In addition, significant postope...Continue Reading

Associated Clinical Trials

Citations

Sep 1, 2018·Current Opinion in Anaesthesiology·Anastasia BorozdinaFederico Bilotta
Feb 15, 2019·Pain Practice : the Official Journal of World Institute of Pain·Martin F Bjurström, Michael R Irwin
Jan 25, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Qiu-Xia XiaoYing Zhang
Sep 12, 2020·Pain Practice : the Official Journal of World Institute of Pain·Zhaoqi WangJun Ma
Jan 30, 2018·Frontiers in Medicine·Sin Wei ChoyChris Moran
Aug 6, 2019·Frontiers in Endocrinology·Daniel P Cardinali
Jul 6, 2018·European Journal of Anaesthesiology·Mark C Kendall, Lucas J Castro-Alves
Oct 23, 2019·Korean journal of anesthesiology·Byung-Gun Lim, Il-Ok Lee
Feb 2, 2019·Frontiers in Psychiatry·Seyed A Safavynia, Peter A Goldstein
Dec 16, 2020·The Cochrane Database of Systematic Reviews·Bennedikte K MadsenJacob Rosenberg
Mar 4, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Annerose MengelMaria-Ioanna Stefanou
May 28, 2021·Annals of Medicine and Surgery·Farshad Hassanzadeh KiabiNegar Shahzadeh Ahmadi
Jun 25, 2021·Frontiers in Medicine·Dandan LinAnshi Wu
Aug 17, 2021·Nature and Science of Sleep·Xuan WangAilin Luo
Nov 4, 2021·Anesthesiology·Brian P O'GaraBalachundhar Subramaniam
Aug 14, 2018·Journal of Clinical Anesthesia·Mark C KendallChristopher J Malgieri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.