The Effect of Melatonin on Superoxide Dismutase and Glutathione Peroxidase Activity, and Malondialdehyde Levels in the Targeted and the Non-targeted Lung and Heart Tissues after Irradiation in Xenograft Mice Colon Cancer

Current Molecular Pharmacology
Seyede Hadis Momeni Hasan AbadiHasan Nosrati

Abstract

Radiation causes damage to irradiated tissues and also tissues that do not receive direct irradiation through a phenomenon called bystander effects. Melatonin as a potent antioxidant and anti-inflammatory agent is known for protection of normal tissues against ionizing irradiation. In addition, some studies have suggested that Melatonin may have some anti-cancer properties. Although the complete mechanisms remain unknown, it can act via immunomodulatory effects. The aim of this study was to evaluate the effect of pretreatment with melatonin on oxidative damage caused by direct irradiation and bystander effects on the lung and heart tissue after xenograft mice colon cancer irradiation in Balb/c mice. Forty nine (49) Balb/c mice were evenly divided into 7 groups including control, irradiation of 5 Gy directly to tumor, melatonin treatment (20 mg/kg) and irradiation (5 Gy single fraction) directly to tumor, irradiation of 5 Gy directly to chest area, melatonin treatment (20 mg/kg) and radiation directly to chest, only melatonin treatment and whole-body scatter group (which gave radiation dose equal to the amount of radiation that the lung had received from the localized pelvic irradiation) to evaluate the effect of melatonin on th...Continue Reading

Citations

Apr 6, 2019·Medicinal Research Reviews·Emilio Gil-MartínAlejandro Romero
May 12, 2019·Medicina·Ahmed Eleojo Musa, Dheyauldeen Shabeeb
Jun 13, 2019·Journal of Cellular and Molecular Medicine·Ruhui YangSongquan Wu
Mar 7, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Adejoke Yetunde OnaolapoOlakunle James Onaolapo
Sep 3, 2020·European Journal of Pharmacology·Mohammad Hossein PourhanifehAzam Hosseinzadeh
May 28, 2021·Frontiers in Oncology·Marike W van GisbergenLudwig J Dubois
Apr 1, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lirong YiJianxiang Liu
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·Kamal Fatima ZahraDaniel Timofte

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