The effect of melatonin supplementation on the quality of sleep and weight status in postmenopausal women

Przegla̜d menopauzalny = Menopause review
E Walecka-KapicaC Chojnacki

Abstract

We evaluated the effect of melatonin supplementation on the nutritional status of postmenopausal women. The study included 56 women (51-65 years) and 25 healthy women (27-36 years). The emotional state was assessed using Hamilton Depression Rating Scale (HAM-D), the quality of sleep using Insomnia Severity Index (ISI). Body mass index (BMI) and waist-hip ratio (WHR) were also calculated. The patients were divided into 3 groups: group I (control) - 25 women with normal body weight, group II - 26 postmenopausal women with normal body weight, group III - 30 postmenopausal women with high body weight. In women from group II and III, routine laboratory tests, levels of thyroid-stimulating hormone (TSH), 17β-estradiol, prolactin, follicle-stimulating hormone (FSH) and the concentration of 6-hydroxymelatonin sulphate (6-HMS) in day/night urine fractions were determined. On the day of the examination, women remained on a liquid diet (1800 kcal). Next, a balanced diet of 1500 kcal and 5 mg of melatonin administration were recommended. The follow-up examinations were performed after 4, 8, 12, 16, 20 and 24 weeks. The patients from groups II and III showed similar mild levels of anxiety and depression and a significant degree of sleep dis...Continue Reading

Citations

Jan 9, 2015·International Journal of Molecular Sciences·Ewa Walecka-KapicaCezary Chojnacki
Jun 21, 2017·BioMed Research International·Cezary ChojnackiJan Chojnacki
Oct 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rafael GenarioHeitor O Santos
Aug 24, 2021·BioMed Research International·Salman MohammadiAli Ghaffarian-Bahraman

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Methods Mentioned

BETA
hormone replacement therapy
pharmacotherapy

Software Mentioned

Stat
STATISTICA

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