The effect of membrane characteristics on tumour necrosis factor kinetics during haemodialysis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
J GhysenC van Ypersele de Strihou

Abstract

We measured serum beta 2-M and TNF alpha before and after a 4-h haemodialysis performed on two membranes with different characteristics, either cuprophane (n = 40) or polyacrylonitrile (AN69) (n = 31). Kinetic studies including determinations at 0, 15, 30, 60 and 240 min were also performed during haemodialysis sessions on cuprophane (n = 14) and AN69 (n = 12). After a 240-min haemodialysis, TNF alpha increased on cuprophane (21.95 +/- 3.46 to 37.20 +/- 4.60 pg/ml, P less than 0.001) but remained stable on AN69 (16.70 +/- 2.60 to 19.90 +/- 2.90 pg/ml, NS). Kinetic studies revealed that on cuprophane, beta 2-M increased progressively from 40.72 +/- 4.41 to 45.71 +/- 4.77 mg/l (P less than 0.001) at 240 min with a significant increase already noted at 60 min. TNF alpha remained stable during the first 60 min but increased significantly at 240 min (34.14 +/- 6.60 to 49.71 +/- 8.78 pg/ml, P less than 0.001). The percentage increment in TNF alpha (50.5%) was significantly greater at 240 min than the percentage increment in beta 2-M (13.4%), a finding suggestive of net generation of TNF alpha. On AN69, beta 2-M decreased progressively from 31.82 +/- 2.70 to 27.30 +/- 2.26 mg/l (P less than 0.001). TNF alpha decreased transiently at 1...Continue Reading

Citations

Apr 17, 2004·Kidney International·Vaidyanathapuram S BalakrishnanUNKNOWN HEMO Study Group
Dec 14, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Vanessa García MoreiraFrancisco V Alvarez Menéndez
Nov 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J L MegeM Olmer
Oct 27, 2001·Seminars in Dialysis·C TielemansH Schiffl
Sep 17, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T VraetzL Graeve
Feb 28, 2017·Blood Purification·Jonathan WongKen Farrington
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Vaidyanathapuram S BalakrishnanBrian J G Pereira
Dec 10, 1991·Clinical Materials·R Vanholder

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