The effect of membrane domains on the G protein-phospholipase Cbeta signaling pathway.

Critical Reviews in Biochemistry and Molecular Biology
Urszula Golebiewska, Suzanne Scarlata

Abstract

The plasma membrane serves as a barrier to limit the exit and entry of components into and out of the cell, offering protection from the external environment. Communication between the cell and the external environment is mediated by multiple signaling pathways. While the plasma membrane was historically viewed as a lipid bilayer with freely diffusing proteins, the last decade has shown that the lipids and proteins in the plasma membrane are organized in a non-random manner, and that this organization can direct and modify various signaling pathways in the cell. In this review, we qualitatively discuss the ways that membrane domains can affect cell signaling. We then focus on how membrane domains can affect a specific signaling pathway--the G protein-phospholipase Cbeta pathway and show how membrane domains can play an active role in directing or redirecting G protein signals.

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Citations

Dec 17, 2011·The Journal of Comparative Neurology·Hiromi Takahashi-Iwanaga, Toshihiko Iwanaga
May 8, 2016·Chemistry and Physics of Lipids·Trivikram R Molugu, Michael F Brown
Sep 2, 2016·Nature Communications·Wenbin ZhongDaoguang Yan
Nov 2, 2013·Biology of the Cell·A Soledad CoriaAlberto M Díaz Añel
Mar 2, 2012·Biotechnology Journal·Ziya Kalay
Jul 23, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Semen V NesterovVladimir N Uversky
Oct 30, 2012·Biochemistry·Rhodora Cristina Calizo, Suzanne Scarlata

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