The effect of membrane exposure on the outcome of regenerative procedures in humans: a meta-analysis

Journal of Periodontology
E E Machtei

Abstract

The significance of early membrane exposure on the regenerative outcome in guided tissue regeneration (GTR) and guided bone regeneration (GBR) procedures is somewhat controversial. Several clinical trials have shown better response when the membranes remained submerged (S) compared to those that have become exposed (E) during healing. Other studies have failed to show any such difference. Small sample size and/or large standard deviation of the changes might account for these discrepancies. The purpose of this meta-analysis is to critically combine the existing data in order to provide meaningful information based on a large database. Studies of GTR in Class II furcation and intrabony defects (IBD), together with GBR around dental implants, where the membrane became exposed during the postoperative period, were combined to form 3 separate databases. A meta-analysis was employed to compare the 2 subgroups (E versus S) in each of the databases. First, weighted mean changes and weighted standard errors were calculated for each subgroup. Next, an individual study P value was calculated (1-tailed Student t test); finally, a combined Fisher's P statistic (with 5% significance level) was calculated from the individual P values. Five s...Continue Reading

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Citations

May 14, 2011·Odontology·Khalid Al-HezaimiTerrence Griffin
Mar 30, 2006·Implant Dentistry·Hom-Lay Wang, Lakshmi Boyapati
Aug 12, 2009·Implant Dentistry·Angie LeeHom-Lay Wang
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