The effect of mental arithmetic in normotensive and hypertensive subjects, and its modification by beta-adrenergic receptor blockade

British Journal of Clinical Pharmacology
G NybergG S Stokes

Abstract

1 The effects of a 5-min period of sustained mental arithmetic upon blood pressure and heart rate were determined in several groups of healthy subjects and hypertensive patients. 2 The arithmetic produced significant increases in heart rate and blood pressure (both systolic and diastolic) in both normotensive and hypertensive subjects. 3 The blood pressure changes were neither attenuated nor enhanced by the prior administration of basis. 4 In subjects habituated to the test the heart rate increase was unaffected by the drugs, but in those less familiar with the test it was usually attenuated. 5 Although the beta1-adrenoceptor selective blocker, metoprolol, caused decreases in baseline values for blood pressure and heart rate similar to those observed with the use of the two non-selective blockrs, it was shown in a double-blind crossover comparison with propranolol that the haemodynamic changes provoked by the mental arithmetic were not less in the presence of beta1-receptor blockade than when both beta1- and beta2-receptors were blocked. 6 These findings suggest that, during beta2-adrenoceptor blockade, the haemodynamic effects of minor mental stress are not exaggerated because of uncompensated alpha-receptor mediated vasoconst...Continue Reading

Citations

Apr 23, 1999·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·A C NóbregaP P Soares
Apr 1, 1979·British Journal of Clinical Pharmacology·D N BatemanC T Dollery
Aug 28, 1982·British Medical Journal·G NybergA Sandström
Jun 1, 1981·British Heart Journal·M W Millar-CraigE B Raftery
Jan 1, 1980·Pharmacology & Therapeutics·B N Prichard, C W Owens
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·S Julius, A B Weder
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·E AmbrosioniB Magnani
Feb 24, 2009·La Presse médicale·Xavier Girerd, Boris Hansel
Jan 1, 1985·European Journal of Clinical Pharmacology·Z Subhan, I Hindmarch
Dec 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·E A TaylorP Turner
Jan 1, 1982·Acta Anaesthesiologica Scandinavica. Supplementum·O WernerK I Pettersson
Apr 1, 1987·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S K Chaturvedi

Related Concepts

Related Feeds

Absence Epilepsy

Absence epilepsy is a common seizure disorder in children which can produce chronic psychosocial sequelae. Discover the latest research on absence epilepsies here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

JAMA : the Journal of the American Medical Association
L J Lyon, M A Nevins
JAMA : the Journal of the American Medical Association
E A AmsterdamS Wolfson
© 2021 Meta ULC. All rights reserved