PMID: 3035529Mar 1, 1987

The effect of mercury chloride and methyl mercury on brain microsomal Na+-K+-ATPase after partial delipidisation with Lubrol

Pharmacology & Toxicology
S MagourH Greim


The microsomal Na+-K+-ATPase of rat brain was inhibited by mercury chloride and methyl mercury. The IC50 was 6.5 X 10(-7) M for mercury chloride and 3.5 X 10(-6) M for methyl mercury. The inhibition was of a non-competitive type with respect to ATP. The non-ionic detergent Lubrol potentiated the inhibitory effect of both mercurials. It is concluded that Lubrol removes the bulk lipids present outside the catalytic center of the enzyme. Consequently, the enzyme will become more sensitive to the inhibition by both mercurials.


Sep 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·B Brokstad Herlofson, A Røed
Mar 20, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Gabriela Poltronieri Souza de AssisDalton V Vassallo
Aug 21, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·C M MoreiraD V Vassallo
Aug 29, 2012·Journal of Biomedicine & Biotechnology·Ige Joseph Kade
Dec 1, 1994·Cellular and Molecular Neurobiology·J GyöriJ Salánki
Jul 1, 2005·Environmental Toxicology and Pharmacology·Diego FalcochioDalton V Vassallo
Jun 15, 1989·Toxicology and Applied Pharmacology·M F HareI A Michaelson
Mar 9, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hesham S ElsabbaghOsama S El-tawil
Apr 13, 1999·Toxicology and Applied Pharmacology·D V VassalloT C Veloso
Jul 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·L MassaroniD V Vassallo
Aug 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L V RossoniD V Vassallo
Dec 6, 2005·The Journal of Pharmacology and Experimental Therapeutics·Bohumila TarabováL'ubica Lacinová

Related Concepts

Mercuric chloride
Methylmercury Compounds
Na(+)-K(+)-Exchanging ATPase

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.