The effect of metabolic alkalosis on central and peripheral mechanisms associated with exercise-induced muscle fatigue in humans

Experimental Physiology
Jason C Siegler, Paul W M Marshall

Abstract

What is the central question of this study? Does metabolic alkalosis affect central and peripheral mechanisms associated with exercise-induced muscle fatigue in humans? What is the main finding and its importance? Inducing metabolic alkalosis before exercise preserved voluntary activation, but not muscle excitation, after a 2 min maximal voluntary contraction (MVC) followed by ischaemia. An effect of pH was also observed in maximal rates of torque development, where alkalosis mitigated the reduction in maximal rates of torque development after the initial 2 min MVC. For the first time, these results demonstrate a differential effect of pH on voluntary activation as well as maximal rates of torque development after sustained, maximal voluntary knee extension in humans. The increased concentration of protons during fatiguing exercise may contribute to increased activation of group III and IV afferents and subsequently reduced central drive, but this has yet to be confirmed in exercising humans. Here, we determined whether inducing metabolic alkalosis differentially affects descending central drive after fatiguing exercise and whether this effect may, in part, be explained by attenuating group III and IV afferent firing. Eleven me...Continue Reading

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Citations

Mar 31, 2017·European Journal of Applied Physiology·John TemesiGuillaume Y Millet
Jul 9, 2017·European Journal of Applied Physiology·José MiraThomas Rupp
May 11, 2020·European Journal of Applied Physiology·Nathan Philip HiltonLars Robert McNaughton
Dec 22, 2020·Frontiers in Sports and Active Living·Hugo A KerhervéDale Lovell
Sep 11, 2021·Journal of the International Society of Sports Nutrition·Jozo GrgicBill I Campbell

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