The effect of metformin treatment on ovarian stromal blood flow in women with polycystic ovary syndrome

Archives of Gynecology and Obstetrics
Emel Ebru OzcimenHulusi Bulent Zeyneloglu

Abstract

To evaluate the effects of metformin on the ovarian stromal blood perfusion in the patients with polycystic ovary syndrome (PCOS). Twenty-five women with PCOS who underwent a Doppler examination of the ovarian stroma was evaluated; hormonal, anthropometric, and biochemical parameters of patients were determined. After the patients were treated with 850 mg metformin twice a day for 6 months, the same parameters were evaluated in the same patients. After metformin treatment, although pulsatility index (PI) was increased from 1.80 +/- 1.23, 1.84 +/- 1.28 to 2.20 +/- 1.10, 2.19 +/- 0.83 in the right and left ovary, respectively, and resistance index was increased from 0.84 +/- 0.25, 0.83 +/- 0.23 to 1.16 +/- 0.37, 1.10 +/- 0.26 in the right and left ovary respectively (P < 0.05), peak systolic velocity (PSV) was decreased from 12.30 +/- 1.72, 12.34 +/- 1.55 to 10.25 +/- 0.97, 10.53 +/- 1.33 in the right and left ovary respectively (P < 0.05). PI and RI did not show any difference between the homeostatic model assessment insulin resistance index (HOMA-IR) >or= 2.38 and HOMA-IR < 2.38 groups before and after metformin treatment (P > 0.05). However, PSV was decreased significantly from 13.05 +/- 1.35, 12.82 +/- 2.02 to 11.03 +/- 0.71,...Continue Reading

References

Dec 1, 1986·The Journal of Endocrinology·J K Findlay
Aug 1, 1981·American Journal of Obstetrics and Gynecology·R HatchD Tredway
Sep 28, 1995·The New England Journal of Medicine·S Franks
Jan 1, 1995·American Journal of Obstetrics and Gynecology·C BattagliaA R Genazzani
Aug 1, 1993·Human Reproduction·A J DulebaY S Moon
Feb 29, 1996·The New England Journal of Medicine·C J Bailey, R C Turner
Apr 17, 1999·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·M DolzF Bonilla-Musoles
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Richard FlemingNaveed Sattar
Jun 12, 2002·Fertility and Sterility·Silvia AjossaGian Benedetto Melis
Dec 31, 2002·Journal of Assisted Reproduction and Genetics·I Y JärveläG Nargund
Jul 2, 2003·Human Reproduction·Mohammad Ebrahim ParsanezhadErnst Heinrich Schmidt
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
May 10, 2005·European Journal of Endocrinology·E Diamanti-KandarakisM Mavrikakis
May 17, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jolanta Nawrocka, Andrzej Starczewski
Mar 25, 2008·Diabetes Research and Clinical Practice·Canan ErsoySazi Imamoglu

❮ Previous
Next ❯

Citations

Aug 21, 2010·Current Opinion in Obstetrics & Gynecology·Niki Katsiki, Apostolos I Hatzitolios
Nov 8, 2013·Archives of Gynecology and Obstetrics·Ahmed K MakledRania Elkabarity
Jan 11, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ali Cenk ÖzayBülent Gülekli
Jan 16, 2014·The Journal of Clinical Endocrinology and Metabolism·Solhild StridsklevEszter Vanky
Sep 7, 2018·International Journal of Endocrinology·Solhild StridsklevEszter Vanky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
W P MartinsC O Nastri
International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Manal M El BeheryAmal E Shehata
Expert Opinion on Emerging Drugs
Colin G Perry, John R Petrie
© 2021 Meta ULC. All rights reserved