The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
A K NordklintP Eiken

Abstract

Some antihyperglycemic medications have been found to affect bone metabolism. We assessed the long-term effects of metformin compared with placebo on bone mineral density (BMD) and trabecular bone score (TBS) in patients with type 2 diabetes. Metformin had no significant effect on BMD in the spine and hip or TBS compared with a placebo. Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fractures despite a high bone mass. Some antihyperglycemic medications have been found to affect bone metabolism. We assessed the long-term effects of metformin compared with placebo on bone mineral density (BMD) and trabecular bone score (TBS). This was a sub-study of a multicenter, randomized, 18-month placebo-controlled, double-blinded trial with metformin vs. placebo in combination with different insulin regimens (the Copenhagen Insulin and Metformin Therapy trial) in patients with T2DM. BMD in the spine and hip and TBS in the spine were assessed by dual-energy X-ray absorptiometry at baseline and after 18 months follow-up. Four hundred seven patients were included in this sub-study. There were no between-group differences in BMD or TBS. From baseline to 18 months, TBS decreased significantly in both groups (metformin gr...Continue Reading

Associated Clinical Trials

References

Jun 28, 2006·Diabetes Care·Mohsen JanghorbaniFrank Hu
Oct 28, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Vestergaard
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonSundeep Khosla
Mar 10, 2009·Diabetes, Obesity & Metabolism·L Lundby ChristensenUNKNOWN CIMT Trial Group
May 28, 2010·Diabetes Care·Woon-Puay KohMimi C Yu
Jun 4, 2010·International Journal of Clinical Practice·E A GrecoS Migliaccio
Jan 24, 2013·The Journal of Clinical Endocrinology and Metabolism·William D LeslieUNKNOWN Manitoba Bone Density Program
Mar 2, 2013·The Journal of Clinical Endocrinology and Metabolism·John P BilezikianLorraine A Fitzpatrick
Aug 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Preethi SrikanthanArun S Karlamangla
Oct 25, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eleanor J HothersallHelen M Colhoun
Jan 21, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Barbara C SilvaJohn P Bilezikian
Mar 19, 2014·Journal of Bone and Mineral Metabolism·Sahar Kamal Hegazy
Apr 11, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R DhaliwalA M Moses
Nov 5, 2014·The Journal of Clinical Endocrinology and Metabolism·Jung Hee KimChan Soo Shin
Dec 17, 2014·International Journal of Clinical Practice·A Oldroyd, S Dubey
Mar 5, 2015·Endocrine Reviews·Matthew P Gilbert, Richard E Pratley
May 28, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jessica ZibelliniAmanda Sainsbury
Jul 4, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V V ZhukouskayaI Chiodini
Aug 6, 2015·European Journal of Endocrinology·Jakob Starup-Linde, Peter Vestergaard
Sep 15, 2015·The Lancet. Diabetes & Endocrinology·Vikram V ShanbhogueMary L Bouxsein
Oct 27, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
Sep 7, 2016·Calcified Tissue International·G Isanne Schacter, William D Leslie
Nov 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Sumit R MajumdarJohn A Kanis
Nov 7, 2016·Calcified Tissue International·Manju Chandran
Nov 11, 2016·Calcified Tissue International·Nicolas Bonnet
Mar 11, 2017·Calcified Tissue International·Jennifer S Walsh, Tatiane Vilaca
Apr 30, 2017·Diabetologia·Ann V Schwartz
Jul 19, 2017·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Rajesh K Jain, Tamara Vokes
Jan 1, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V N ShahJ K Snell-Bergeon

❮ Previous
Next ❯

Citations

Feb 18, 2019·Endocrine Connections·Ann-Kristin PickeMartina Rauner
Jun 21, 2019·Journal of Diabetes·Jian-Min LiuUNKNOWN Chinese Society of Osteoporosis and Bone Mineral Research, the Chinese Society of Endocrinology, Chinese Diabetes Society, C
Jul 4, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard H LeeCathleen Colón-Emeric
Mar 16, 2019·Current Obesity Reports·Armen Yerevanian, Alexander A Soukas
Feb 2, 2019·Journal of Bone and Mineral Metabolism·Jianrong ZhaoLi Zuo
Feb 18, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A K NordklintP Eiken
Apr 3, 2021·Calcified Tissue International·Abdul Rahaman ShaikSerge Livio Ferrari
Nov 12, 2021·Archives of Endocrinology and Metabolism·Luciana Muniz PechmannVictoria Z C Borba

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
A U LarsenR Jorde
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
R DhaliwalA M Moses
Metabolism: Clinical and Experimental
Rajesh GargMeryl S LeBoff
© 2022 Meta ULC. All rights reserved