The effect of methadone on blood glucose, lipids and glucose-modulating hormones in methadone-dependent Wistar rats.

Toxicological Research
Zoya TahergorabiMitra Moodi

Abstract

A growing body of evidence indicates that opioids regulate mechanisms activated during the stress response. This study was aimed to investigate the effect of methadone dependency on blood glucose, lipids and glucose-modulating hormones in male and female Wistar rats.This study was performed on 40 Wistar rats weighing 150-350 g, in four methadone exposure and control groups of both males and females. All rats were weighed at the beginning and end of the study and their fasting blood glucose was measured using a glucometer. In order to induce addiction, methadone was injected intraperitoneal for 10 consecutive days at 5 mg/kg dose. The control group received the same volume of only normal saline. At the end of the study, the rats were sacrificed and their blood serum collected to measure cortisol, glucagon, adrenaline and lipid profile levels.There was a significant decrease in the mean final blood glucose of methadone-treated versus control male rats (p = 0.02). There was no significant glucose difference, however, in female rats. Furthermore, a decrease in the mean serum levels of triglyceride, cortisol, and adrenaline occurred in male rats of methadone-dependent compared with control animals, but there was no significant diffe...Continue Reading

References

Nov 1, 1996·Journal of Pharmacological and Toxicological Methods·T L PierceC Raper
Jan 1, 1997·General Pharmacology·D SadavaD P Pettit-Barrett
Jun 1, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·G DroletJ F Trottier
Feb 24, 2007·Physiology & Behavior·Pawel K Olszewski, Allen S Levine
Apr 21, 2009·Current Opinion in Psychiatry·Chuan-Yu Chen, Keh-Ming Lin
Nov 12, 2009·Endocrine Reviews·Cassidy VuongTheodore C Friedman
Mar 17, 2010·Neuroscience Letters·Soo-Hyun ParkHong-Won Suh
Aug 17, 2012·Journal of Addiction Medicine·Shih-Hsien LinKao Chin Chen
Mar 8, 2013·Cellular and Molecular Neurobiology·Andrew J FaskowitzGavril W Pasternak
May 28, 2013·Journal of Opioid Management·Natalie MorylEugenie Obbens
Dec 3, 2014·Journal of Substance Abuse Treatment·Jennifer M FennStacey C Sigmon
Sep 8, 2015·Journal of Pain and Symptom Management·James H FloryNatalie Moryl
Apr 11, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanni C SantoroStephen L Dewey
Jun 27, 2017·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Michael S ToceMichele M Burns
Mar 14, 2018·Bulletin of the World Health Organization·Talat GhaneAlireza Noroozi
Feb 16, 2019·Toxicological Research·Shahrzad Bozchelou, Mohammad Delirrad

❮ Previous
Next ❯

Citations

Nov 13, 2020·Journal of Diabetes Research·El-Shaimaa A ArafaManal Ali Buabeid

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Metabolism and Disposition : the Biological Fate of Chemicals
T C SpauldingA E Takemori
Ugeskrift for laeger
T B Madsen
The Medical Journal of Australia
G Milner
Canadian Family Physician Médecin De Famille Canadien
Denise J Denning
The Medical Journal of Australia
D S Bell
© 2021 Meta ULC. All rights reserved