The effect of methotrexate and hydroxyurea on neutrophil chemotaxis

The British Journal of Dermatology
J J Cream, D S Pole

Abstract

Methotrexate depresses motility of neutrophils in chamber membranes, but does not interfere with random motility in tubes. Hydroxyurea has no such effect. The therapeutic response to methotrexate in psoriasis may be due in part to a reduction in migration of neutrophils into the epidermis.

References

Jan 1, 1979·Journal of Immunological Methods·J J Cream, D S Pole
Jan 1, 1978·The Journal of Investigative Dermatology·N B EsterlyL E Flanagan
Apr 1, 1978·The Journal of Investigative Dermatology·A E NewburgerJ L McCullough
Feb 1, 1977·The Journal of Investigative Dermatology·B A FlaxmanA M Feldman
Apr 1, 1977·Antimicrobial Agents and Chemotherapy·A Forsgren, D Schmeling
Mar 1, 1971·Archives of Dermatology·K M HalprinA Okawara

❮ Previous
Next ❯

Citations

Jan 1, 1988·Rheumatology International·J W O'CallaghanP M Brooks
Oct 1, 1992·Inflammation·B N Cronstein
Jan 17, 2004·Journal of the American Academy of Dermatology·Frank C Saporito, M Alan Menter
Jul 3, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Matt Morgan, David A Khan
Nov 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·S R NimmagaddaS J Szefler
May 18, 1999·Current Opinion in Rheumatology·M Seitz
May 1, 1995·Thorax·J M Hill, A E Tattersfield
Jan 1, 1991·The American Review of Respiratory Disease·G JonesJ Karsh
Aug 1, 1996·American Journal of Respiratory and Critical Care Medicine·W W BusseN N Jarjour
Oct 1, 1988·European Journal of Pediatrics·P C van de KerkhofR Holland
Jan 1, 1991·Immunopharmacology and Immunotoxicology·G F WeberJ M McCord
Jan 1, 1992·Immunopharmacology and Immunotoxicology·G F Weber, M G Nair
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J Alvarez, S J Szefler
Aug 1, 1991·Journal of the American Academy of Dermatology·E A Olsen
Mar 1, 1990·Journal of the American Academy of Dermatology·M D ZanolliA E Hedberg
Jun 1, 1991·Journal of the American Academy of Dermatology·J L JorizzoE F Sherertz
Nov 12, 2009·The British Journal of Dermatology·A PerezC E H Grattan
Dec 1, 1990·Seminars in Arthritis and Rheumatism·R SegalB Tartakovsky
May 1, 1983·Seminars in Arthritis and Rheumatism·G D GroffT H Taylor
Apr 1, 1983·The British Journal of Dermatology·U WalsdorferJ M Schröder
Nov 15, 1997·Rheumatic Diseases Clinics of North America·J L Hillson, D E Furst
Aug 1, 1993·Respiratory Medicine·J L YntemaR Aalbers
Sep 5, 2001·The British Journal of Dermatology·J E GachA K Black
Sep 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D M Geddes
Sep 1, 1985·The British Journal of Dermatology·P C van de KerkhofR M Maassen-de Grood
Jun 1, 1986·Arthritis and Rheumatism·H Truckenbrodt, R Häfner
Sep 30, 2020·Expert Opinion on Pharmacotherapy·Kam Lun HonVivian W Y Lee
Mar 1, 1988·Arthritis and Rheumatism·D E Furst, J M Kremer
Nov 1, 1996·Clinical and Experimental Dermatology·M J Boffa, R J Chalmers
Mar 10, 1988·The New England Journal of Medicine·M F MullarkeyC E Wetzel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.