PMID: 16523669Mar 10, 2006Paper

The effect of methyl-containing supplements during pregnancy on the phenotypic modification of offspring hair color in rats

Genetika
L A PrasolovaI F Latypov

Abstract

The effect of methyl supplements to the diet of pregnant homozygous (AAHH) female rats with agouti coat color mated with homozygous (aahh) males on the phenotypic modification of the coat color of their heterozygous offspring (AaHh) has been studied. Comparative morphological analysis of the main parameters of hair that determine coat color, including the total length of hairs of different types and the length of the upper black (eumelanin) and light (pheomelanin) parts of awn hairs has been performed. The pattern of pigment granule distribution among hair layers has been analyzed. The melanin content of the hair has been determined using electron spin resonance (ESR). Although all offspring have a typical agouti coat color (alternating black and light portions of hair), 39% of them have a darker coat color than control and other experimental rats have. The main differences between the offspring with darkened and standard coat colors are accounted for by the ratio between the eumelanin and pheomelanin portions of awn hairs. In darkened offspring, this ratio is significantly higher than in control rats. The possible mechanisms of the phenotypic modification of agouti coat color in experimental animals are discussed.

References

Feb 1, 1991·Pigment Cell Research·E B VsevolodovI F Latypov
Aug 1, 1996·Trends in Genetics : TIG·G S Barsh
Jun 19, 2002·Journal of Theoretical Biology·Leiv ØyehaugStig W Omholt
Jul 16, 2003·Molecular and Cellular Biology·Robert A Waterland, Randy L Jirtle

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Citations

Jul 1, 1994·Neuroscience and Behavioral Physiology·V G Kassil
Jul 2, 2009·Human Reproduction Update·I CetinS Calabrese
Jan 13, 2011·The Journal of Veterinary Medical Science·Daisuke TorigoeTakashi Agui
Oct 1, 2010·Maternal & Child Nutrition·Katalin FeketeTamás Decsi
Oct 7, 2014·Pharmacology, Biochemistry, and Behavior·I I PoletaevaG V Pavlova

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