Abstract
Aim was to investigate the effect of methylprednisolone and tenoxicam on the protection of damage of the nerve physiomorphology caused by prolene mesh used in hernia repair. Fifty male Wistar-albino rats weighing 250-350 gr, were randomly divided into 5 groups. Sciatic nerve was dissected in all rats after performing EMG on basal neural transport. In group 1, only sciatic nerve manipulation was performed. Other groups received a monofilament polypropylene cuff around the sciatic nerve. No additional procedure was performed in group 2. In group 3, 2 mg/kg single dose methylprednisolone was injected around the nerve and mesh. In group 4 and 5, 0.5 mg/kg/day methylprednisolone and 1 mg/kg tenoxicam was injected around the nerve and mesh for 4 weeks, respectively. Neural transport was evaluated by electromyography 4 weeks later and compared with pre-procedural values. Then the rats were sacrificed and, sciatic nerves including 1 cm around the mesh were excised. Inflammation and fibrosis were scored histopathologically. While basal latency was similar, postoperative latency was significantly different among groups. Latency was significantly longer in group 2 than the group 1. It was significantly shorter in group 3 when compared to ...Continue Reading
References
Feb 1, 1991·The British Journal of Surgery·R G MolloyW O Kirwan
Dec 1, 1996·Anesthesia and Analgesia·S S MikkelsenJ B Dahl
Nov 11, 1998·Journal of the American College of Surgeons·C P Heise, J R Starling
Mar 19, 1999·The Journal of Urology·R G UzzoM Goldstein
Dec 6, 2000·The Journal of Surgical Research·K E GreenawaltJ W Burns
Jun 27, 2001·American Journal of Surgery·B KulahF Coskun
Nov 15, 2002·Advances in Therapy·Sercan AkpinarFazilet Kayaselcuk
Oct 31, 2003·Hernia : the Journal of Hernias and Abdominal Wall Surgery·D E TsakayannisD A Linos
Jul 14, 2004·Archives of Surgery·Marcello PicchioAngelo Caliendo
Mar 15, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tamer AkcaSuha Aydin
Jun 1, 2005·Journal of the American College of Surgeons·Simon Willem NienhuijsLuc J A Strobbe
Jul 23, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Huseyin Ayhan KayaogluResit Dogan Koseoglu
Aug 27, 2005·Muscle & Nerve·Fikret BademkiranCumhur Ertekin
Jan 18, 2006·The Journal of Surgical Research·Seher DemirerE Kuterdem
May 20, 2006·Hernia : the Journal of Hernias and Abdominal Wall Surgery·E K AasvangH Kehlet
Jun 15, 2007·World Journal of Surgery·M J A LoosM R M Scheltinga
Oct 29, 2008·Journal of the American College of Surgeons·Namik OzkanEbru Arabaci