The effect of methylprednisolone treatment on cerebral reactivity in patients with multiple sclerosis

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Serhat OzkanGazi Ozdemir

Abstract

We assessed the effect of intravenous high-dose methylprednisolone (IVMP) on cerebral reactivity in multiple sclerosis (MS) patients during exacerbations by means of functional transcranial Doppler imaging. Forty-eight clinically defined MS patients were evaluated with visual evoked potentials (VEP) and functional transcranial Doppler sonography (TCD) of both posterior cerebral arteries before and after 5 days of 1000 mg IVMP. After treatment, mean Expanded Disability Status Scale score, mean blood flow velocities and mean blood flow velocities at rest and at stimulation, significantly decreased (p < 0.0001, for each). The change in cerebral blood flow velocity ratio (CBFv) with visual stimulation after treatment increased slightly (p = 0.20). All TCD parameters were not significantly correlated with VEP changes. In conclusion, we observed significant changes in CBFv with a non-significant increase in vascular reactivity after treatment with IVMP in exacerbations of MS. Case-control studies are necessary to draw conclusions regarding the beneficial effects of IVMP treatment.

References

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Citations

May 29, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M GonulI Uzunca
May 3, 2016·Clinical Neurology and Neurosurgery·Gulnur Tekgöl Uzuner, Nevzat Uzuner
May 7, 2016·Neurological Research·Revital Gandelman-MartonZeevi Dvir
Jul 7, 2007·Multiple Sclerosis : Clinical and Laboratory Research·N UzunerN Cinar
Jul 4, 2020·Multiple Sclerosis and Related Disorders·Simona LattanziMauro Silvestrini

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