The effect of metoprolol, a new beta1-adrenoceptor blocking agent, was compared to practolol in the treatment of hypertension in seventeen asthmatics during concurrent optimum bronchodilator therapy with a selective beta2-adrenoceptor-stimulant. The two beta-adrenoceptor antagonists were given at two dose levels, practolol (200 mg and 400 mg) daily, and metoprolol (100 mg and 200 mg) daily, in a twice-daily dosage schedule, at 12 h intervals, for 17 days. The comparison was made double-blind and a crossover design was used. The drugs were given in randomized order. The study started with a run-in placebo period and there was a washout period on placebo between the treatment periods. Spirometry, blood pressures and heart rates were recorded in a standardized manner. At the lower dose levels no influence on FEV1 was noted, and no difference was found between the two active drugs. At the higher dose level FEV1 was reduced by both beta-adrenoceptor-blocking drugs. Four out of twelve patients given the higher dose experienced exacerbation of their asthma. The heart rate fell with both drugs and at both dose levels. During the placebo period a marked increase of heart rate was noted. The blood pressure fell at both dose levels compar...Continue Reading
The investigation of critical parameters in the glycolytic response of single living cells by rapid microspectrofluorometric analysis
An eighteen months' study of the clinical response to metoprolol, a selective beta1-receptor blocking agent, in patients with angina pectoris
Antihypertensive effect of beta-1 receptor blockade and beta-2-receptor stimulation in essential hypertension
A specific carrier for O2 and CO in the lung: effects of volatile anesthetics on gas transfer and drug metabolism
The effects of hydralazine administered into the brachial artery on adrenergic vasoconstrictor stimuli in the hand
Dose-response relationship of the beta-adrenoceptor antagonist bisoprolol in patients with coronary heart disease and chronic obstructive bronchitis
Effects of single oral doses of bisoprolol and atenolol on airway function in nonasthmatic chronic obstructive lung disease and angina pectoris
Controlled study of the bronchoconstriction effect of pindolol administered intravenously or orally to patients with unstable asthma
Comparative effects of celiprolol, propranolol, oxprenolol, and atenolol on respiratory function in hypertensive patients with chronic obstructive lung disease
Exercise capacity and ventilatory response during exercise in COPD patients with and without β blockade
Comparison of the duration of antihypertensive action of atenolol and metoprolol over a 24-hour period
Evaluation of the asthmogenicity of propafenone, a new antiarrhythmic drug. Comparison of spirometry with methacholine challenge
Beta-adrenoceptor blockers and terbutaline in patients with chronic obstructive lung disease. Effects and interaction after oral administration
Comparison of the effects of single doses of atenolol and labetalol on airways obstruction in patients with hypertension and asthma
Comparison of the cardiovascular and pulmonary effects of oral celiprolol, propranolol and placebo in normal volunteers
Effects of ICI 141,292 on exercise tachycardia and isoprenaline-induced beta-adrenoceptor responses in man
Optimal heart rate control for patients with chronic atrial fibrillation: are pharmacologic choices truly changing?
Cardioselective beta-blocker treatment of hypertension in patients with asthma: when do benefits outweigh risks?
Osmotic release oral drug delivery system of metoprolol in hypertensive asthmatic patients. Pharmacodynamic effects on beta 2-adrenergic receptors
Under-use of beta-blockers in patients with ischaemic heart disease and concomitant chronic obstructive pulmonary disease
An official American Thoracic Society/European Respiratory Society statement: research questions in COPD
Cardioselective beta-blockers in patients with asthma and concomitant heart failure or history of myocardial infarction: when do benefits outweigh risks?
Allergy and Asthma
Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.
This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.
Adrenergic Receptors: Trafficking
Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.