The effect of microvascular pattern alterations on network resistance in spontaneously hypertensive rats.

Medical & Biological Engineering & Computing
Ming Yang, Walter L Murfee

Abstract

Structural microvascular rarefaction, defined by a loss of vessels, is a common characteristic of hypertension and has been associated with elevated microvascular resistance. However, determining the causal relationship between microvascular network structure and resistance requires a consideration of all pattern changes throughout a network. The objectives of this study were to determine whether microvascular rarefaction is associated with other network pattern alterations and to evaluate whether pattern alterations in hypertension necessarily contribute to increased microvascular resistance. Mesenteric tissues from age-matched (15-16 weeks) male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were harvested and immunolabeled for PECAM. SHR networks displayed a decreased microvascular area, arteriolar-venular (AV) length, number of AV branches, and number of capillary segments. In addition, SHR networks displayed increased AV connections per network compared to WKY networks. Based on network geometries, resistance per network was calculated using a computational model. For simulations with equal vessel diameter and with relative diameters based on reported intravital measurements, SHR microvascul...Continue Reading

References

Jul 18, 1978·Pflügers Archiv : European journal of physiology·H HenrichR Assmann
Nov 1, 1978·Microvascular Research·R N HarperP M Hutchins
Jan 1, 1977·Microvascular Research·H G BohlenP M Hutchins
Oct 1, 1990·Circulation Research·A R PriesJ F Gross
Jan 15, 1988·Klinische Wochenschrift·H A HenrichF Bäumer
Feb 1, 1987·Hypertension·G W Schmid-SchönbeinP C Chen
Mar 1, 1986·Hypertension·J L Borders, H J Granger
Jul 1, 1984·Hypertension·J H LombardW J Stekiel
Nov 1, 1994·Circulation Research·A R PriesP Gaehtgens
May 1, 1995·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·R J Price, T C Skalak
Nov 1, 1995·The Journal of Physiology·J Fenger-GronK L Christensen
Nov 1, 1995·International Journal of Microcirculation, Clinical and Experimental·H SuzukiG W Schmid-Schönbein
Jul 31, 1998·American Journal of Hypertension·D LominadzeD A Schuschke
Dec 18, 1998·Journal of Hypertension·F A le NobleH A Struijker Boudier
Apr 16, 1999·Hypertension·T F AntoniosG A MacGregor
May 10, 2000·The American Journal of Cardiology·R B DevereuxJ H Laragh
Aug 8, 2001·Circulation·B I LevyH A Struijker-Boudier
Aug 2, 2002·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Makoto SuematsuGeert W Schmid-Schönbein
Nov 27, 2002·Clinical and Experimental Hypertension : CHE·Daniele TomassoniFrancesco Amenta
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
May 29, 2004·Circulation Research·Shunichi FukudaGeert W Schmid-Schönbein
May 29, 2004·Journal of Hypertension·Björn Folkow
Jul 23, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Nobuhiko KobayashiGeert W Schmid-Schönbein
Apr 22, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Walter L MurfeeThomas C Skalak
Apr 25, 2007·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Kyle W BinderRichard J Price
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neeltje SteeghsEelco de Koning
Nov 15, 2008·Methods in Enzymology·Walter L Murfee, Geert W Schmid-Schönbein
Jul 25, 2009·Clinical Hemorheology and Microcirculation·Silvia PaiardiEnrico Agabiti-Rosei
Mar 23, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Edward D TranGeert W Schmid-Schönbein
Jun 2, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Ming YangWalter L Murfee
Oct 1, 2011·Microvascular Research·Peter C Stapor, Walter L Murfee

❮ Previous
Next ❯

Citations

Jan 8, 2014·Infectious Diseases in Obstetrics and Gynecology·Ahmet Bariş GüzelMacit Ilkit
Apr 18, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·So Yon ParkBermseok Oh
Nov 20, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Richard S SweatWalter L Murfee
Apr 8, 2020·Current Eye Research·Yunxia LiTimothy Q Duong
Mar 21, 2020·Journal of Hypertension·Vinicius P GarciaNatália G Rocha
May 7, 2020·Journal of Hypertension·Vinicius P GarciaNatália G Rocha
Oct 8, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Suraj KrishnanRajesh Mohandas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Ming YangWalter L Murfee
Methods in Enzymology
Walter L Murfee, Geert W Schmid-Schönbein
Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Jerome AellenBernard Waeber
© 2021 Meta ULC. All rights reserved