The effect of migraine prophylaxis on migraine-related resource use and productivity

CNS Drugs
Miguel J A Láinez

Abstract

In the US, it is estimated that up to 10% of men and 25% of women, particularly those aged 25-55 years, experience debilitating migraines, such that the condition presents an enormous economic burden for patients, health systems, employers and society. Migraine headache is a particularly prevalent condition associated with major reductions in patients' quality of life. From a payer perspective, the implementation of relevant programmes of migraine prophylaxis is highly desirable. Consistent evidence exists, from several randomized, controlled studies, of the efficacy of amitriptyline, divalproex sodium, propranolol, timolol and topiramate in migraine prophylaxis. Considering resource utilization, various studies suggest that migraine prophylaxis with antiepileptics, antidepressants, beta-blockers or calcium channel antagonists markedly reduces triptan use and visits to physician offices and emergency departments (EDs), without compromising quality of care or treatment outcomes. Over recent years, the effects of topiramate in reducing resource utilization in patients with migraine have been relatively widely studied. In US claims database analyses involving >4000 patients with migraine, topiramate significantly reduced triptan u...Continue Reading

References

Jan 7, 1999·Cephalalgia : an International Journal of Headache·J U AdelmanA M Rapoport
Dec 8, 1996·PharmacoEconomics·G D Solomon, K L Price
Apr 29, 1999·Archives of Internal Medicine·X H HuM L Berger
Mar 17, 2001·Headache·N T MathewS Tepper
Jun 6, 2002·Cephalalgia : an International Journal of Headache·H C DienerF De Beukelaar
Nov 28, 2002·Headache·James U AdelmanRandal Von Seggern
Feb 27, 2003·Headache·Stephen D SilbersteinJoseph J Chmiel
Jun 6, 2003·Headache·Morris MaizelsJonathan Wirjo
Nov 25, 2003·Headache·James U AdelmanKaren E Teague
Mar 3, 2004·Journal of Neurology·Hartmut Göbel
Apr 21, 2004·Archives of Neurology·Stephen D SilbersteinUNKNOWN MIGR-001 Study Group
Jul 28, 2004·Neurology·Stephen D SilbersteinCharlotte Keywood
Aug 19, 2004·Journal of Neurology·Hans-Christoph DienerUNKNOWN MIGR-003 Study Group
Nov 18, 2004·Headache·Julio PascualMiguel J Laínez
Nov 18, 2004·Headache·Leon C AdelmanRandal L Von Seggern
Dec 30, 2004·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·D MeiG Di Trapani
Apr 7, 2005·Clinical Therapeutics·Stephen D SilbersteinFrank Wiegand
Nov 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C LamplV Limmroth
Dec 15, 2005·Disease Management : DM·Dexter L Campinha-BacoteAlan F Kaul
Apr 20, 2006·JAMA : the Journal of the American Medical Association·Jan Lewis Brandes
Aug 31, 2006·Expert Opinion on Emerging Drugs·Peter J Goadsby
Sep 9, 2006·Clinical Neuropharmacology·Daniele MeiGirolamo Di Trapani
Sep 15, 2006·Cleveland Clinic Journal of Medicine·Jadwiga Loj, Glen D Solomon
Nov 23, 2006·Cephalalgia : an International Journal of Headache·J S BrownJ Menzin
Apr 21, 2007·Headache·Stephen D SilbersteinStephen J Boccuzzi
Jun 26, 2007·Disease Management : DM·Joshua J GagneStephen Silberstein
Jul 10, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Anthony L FeliuJames Vermilyea
Aug 10, 2007·Expert Opinion on Pharmacotherapy·Avi Ashkenazi, Stephen Silberstein
Oct 24, 2007·The Journal of Headache and Pain·Mario GuidottiCarlo Belloni
Oct 25, 2007·Expert Opinion on Pharmacotherapy·Manuela Fontebasso
Nov 16, 2007·Expert Opinion on Pharmacotherapy·Färkkilä Markus, Kallela Mikko
May 3, 2008·Current Opinion in Neurology·E Anne MacGregor

❮ Previous
Next ❯

Citations

May 6, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Domenico D'AmicoG Bussone
Apr 27, 2010·Lancet·Lars Edvinsson, Mattias Linde
May 31, 2014·Cephalalgia : an International Journal of Headache·Serena L OrrSuzanne N Christie
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Mahmoud BahmaniMahyar Jelodari
Dec 3, 2016·Headache·Stephen D Silberstein
Jul 16, 2019·Clinical Drug Investigation·Theodoros V GiannouchosParaskevi Koufopoulou
Mar 15, 2020·The Journal of Headache and Pain·Andrea NegroPaolo Martelletti
Dec 11, 2020·Expert Review of Neurotherapeutics·Michelangelo LucianiPaolo Martelletti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.