PMID: 6986226Jan 1, 1980Paper

The effect of mineralocorticoid administration on urine free dopamine in man

Clinical Science
N S OatesM R Lee

Abstract

1. Five normal subjects were studied under metabolic conditions on a controlled sodium and potassium intake. 2. Plasma and urine free dopamine concentrations were measured in these subjects before, during and after 5 days administration of fludrocortisone (0.2 mg twice daily). 3. Urine free dopamine showed a tendency to fall during the early phase of fludrocortisone administration and then rose towards normal. 4. In a patient with primary hyperaldosteronism there was no evidence of increased renal production of dopamine. Urine dopamine fell when plasma renin activity rose as a result of spironolactone administration (200 mg three times a day for 5 days). 5. If renal dopamine has a role in mineralocorticoid 'escape' then it may be permissive only. The mechanisms of control of dopamine production could include tubular sodium concentration, tubular chloride concentration and intrarenal renin activity.

Citations

Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·M R Lee
Feb 1, 1982·British Journal of Obstetrics and Gynaecology·C M PerkinsM R Lee
Aug 1, 1981·British Journal of Clinical Pharmacology·M J Brown, D J Allison

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