PMID: 6409460May 1, 1983Paper

The effect of minor increments in plasma thyroxine on heart rate and urinary sodium excretion

Clinical Endocrinology
G M BellA D Toft

Abstract

We studied day/night (D:N) patterns of urinary sodium excretion and the 24 hour ambulatory electrocardiogram in seven normal subjects before and during the administration of T4. Thyroxine increased thyroid hormone levels within the normal range and inhibited the plasma TSH response to TRH. This was associated with a significant decrease in D:N sodium excretion (P less than 0.01) and D:N urine flow (P less than 0.01), a significant increase in mean nocturnal heart rate (P less than 0.01), and a lesser increment in mean daytime heart rate (P less than 0.05). These responses to small changes in thyroid hormone levels suggest that the anterior pituitary is not alone in recognising minor thyroid hormone excess. The clinical implication is that some patients with a normal T3 and T4 but an impaired TSH response to TRH might benefit from antithyroid treatment.

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Citations

Mar 2, 2006·JAMA : the Journal of the American Medical Association·Anne R CappolaPaul W Ladenson
Mar 1, 1996·Trends in Endocrinology and Metabolism : TEM·J A Franklyn, M D Gammage
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Feb 1, 1991·Clinical Endocrinology·A D Toft
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