PMID: 10262Oct 1, 1976

The effect of miotics on the intraocular pressure of conscious owl monkeys

Investigative Ophthalmology
J W Lamble, A P Lamble

Abstract

The intraocular pressure of conscious, unsedated owl monkeys (Aotus trivirgatus) was measured with an applanation tonometer. Untreated eyes of the conscious animals were found to have higher values than those reported for owl monkeys anesthetized with pentobarbitone. Locally applied pilocarpine, carbachol, and oxotremorine gave concentration-related reduction in pressure, oxotremorine being the most potent and having longer duration of effect than the other compounds. Slight reductions were also observed with aceclidine and R. S. 86. These results are discussed in relation to the effects of miotics in man.

Related Concepts

Neural Therapy of Huneke
Anthropoidea
Night Monkey, Northern
Carboptic
Dose-Response Relationship, Drug
Physiologic Intraocular Pressure
Miotic Effect
Oxotremorine
Parasympathomimetic Effect
Salagen

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